Towards an oral influenza vaccine

Sizer, Philip J.H.

doi:10.1016/s0167-7799(97)01070-6

Cited by 12 publications

(5 citation statements)

References 10 publications

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“…Bilosomes (BLS) are locked bilayer nanovesicles consisting of non-ionic surfactants and deoxycholic acid integrated into the liposome membrane [133]. In the pharmaceutical industry, bile salts are usually utilized as penetration enhancers to advance the bioavailability of drugs [134,135]. BLS represent a new generation of nanocarriers due to their superior stability compared to classical liposomes.…”

Section: Niosomesmentioning

confidence: 99%

Prospective role of Citicoline and nanotechnology as drug delivery approaches for Alzheimer’s disease: Review of the literature

AbouElhassan

Sarhan

Hussein

et al. 2022

Journal of advanced Biomedical and Pharmaceutical Sciences

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Alzheimer's disease (AD) represents a degenerative nerve disease that highly occurs in older people, which grow fast across developing countries. A precarious target in the controlling of AD aims at boosting presently accessible pharmacologic therapies' impacts, e.g., Cytidine diphosphocholine (CDP Choline or Citicoline). Citicoline (CT) denotes a food complement utilized as a manager with neuroprotection characteristics for neurological disarrays (including stroke, brain injury, AD, and dementia). Citicoline is a source of choline, which helps to maintain the consistency of neuronal cell membranes and is a significant intermediary in the creation of phosphatidylcholine (essential brain phospholipids). Companies chiefly market most approved drugs for controlling AD as traditional medicines taken via the mouth. Because of the gastrointestinal drawbacks and failure to target the brain, such medications, and dosage regimens obstruct patient obedience and cause stoppage of the treatments. Nanotechnology-based drug delivery systems controlled in various ways are favorable tools in enhancing the compliance of patients and succeeding in improved treatment results. A viable, non-invasive way of delivering medicinal drugs to the brain while bypassing the blood-brain barrier (BBB) is intranasal administration. The literature article was searched in the National Center for Biotechnology Information Advances Science and Health (NCBI), Wiley online library, and Science Direct database utilizing the keywords Alzheimer's disease, Citicoline, and nanotechnology. Articles that appeared appropriate based on title and abstract were included. Also, an individual collection of literature reviews on the therapeutic effects of CT and the lipid-based vesicular system was referred. This article review discusses AD, pathogenesis, therapeutic objectives and treatments, CT therapeutics effect in AD and other central disorders, the types of nanocarriers, intranasal administration. and advantages in brain targeting.

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Section: Niosomesmentioning

confidence: 99%

Prospective role of Citicoline and nanotechnology as drug delivery approaches for Alzheimer’s disease: Review of the literature

AbouElhassan

Sarhan

Hussein

et al. 2022

Journal of advanced Biomedical and Pharmaceutical Sciences

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“…Novel vesicular delivery systems containing bile salts are known as “bilosome”, which act as penetration enhancers and improve bioavailability (Sizer, 1997). Sadeghi et al (2009) developed a gas-empowered delivery system for carbon dioxide-forced transport of the protein to the surface of the small intestine.…”

Section: Formulation Approaches For Oral Delivery Of Proteins and Pepmentioning

confidence: 99%

A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

Muheem

Shakeel

Jahangir³

et al. 2016

Saudi Pharmaceutical Journal

282

127

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In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones are being developed utilizing different sophisticated biotechnological techniques like recombinant DNA technology and protein purification. However, the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation. These problems can be overcome by adopting techniques such as chemical transformation of protein structures, enzyme inhibitors, mucoadhesive polymers and permeation enhancers. Being invasive, parenteral route is inconvenient for the administration of protein and peptides, several research endeavors have been undertaken to formulate a better delivery system for proteins and peptides with major emphasis on non-invasive routes such as oral, transdermal, vaginal, rectal, pulmonary and intrauterine. This review article emphasizes on the recent advancements made in the delivery of protein and peptides by a non-invasive (peroral) route into the body.

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“…Only 30-70% of people aged 65 years or older are successfully immunised against influenza in any one season, compared with a success rate of 70-80% in younger and healthier individuals [1,2]. The problem is further compounded by the fact that more than 40% of high risk individuals do not receive this vaccine [3]. Therefore, it can be concluded that a vaccine with high efficiency together with the ability to increase patient compliance, would reduce the high death rate associated with this seemingly innocuous virus.…”

Section: Introductionmentioning

confidence: 99%

“…Bile salts are commonly used as penetration enhancers by the pharmaceutical industry and promote oral bio-availability [3,5]. In the past, larger and more frequent oral antigen doses were given to overcome the digestive barrier [3,6].…”

Section: Introductionmentioning

confidence: 99%

Bilosomes Based Drug Delivery System

2015

J Chem Appl

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Vesicular carrier systems (liposomes & niosomes) are one of the potential candidates for vaccine delivery by the oral route. But its instability in gastrointestinal environment makes it less applicable to be used for the purpose of oral immunization. This necessitates larger and more frequent doses of antigen for vaccination. Drug delivery system overcomes which a lipid vesicle is containing bile salts (bilosome), which prevents antigen degradation and enhances mucosal penetration. New generation bilosomes are more stable in gastrointestinal tract. This review is sharply focused on comparative overview of liposomes, niosomes and bilosomes. Biolosomes benefits, future perspective, market application characterization and stability of bilosomes.

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Towards an oral influenza vaccine

Cited by 12 publications

References 10 publications

Prospective role of Citicoline and nanotechnology as drug delivery approaches for Alzheimer’s disease: Review of the literature

Prospective role of Citicoline and nanotechnology as drug delivery approaches for Alzheimer’s disease: Review of the literature

A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

Bilosomes Based Drug Delivery System

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