Towards cell therapy of polycystic ovary syndrome (PCOS): human mesenchymal stem cells secretome inhibits androgen production by pcos theca cells

Chugh, Rishi Man; Ashour, Dalia S.; Garcia, Natália; Park, H.; Takala, Hajra; Ismail, Nahed; McAllister, Jan M.; Al-Hendy, Ayman; Andaloussi, A. El

doi:10.1016/j.jcyt.2019.03.493

Cited by 4 publications

(2 citation statements)

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“…Comparable experiments were conducted on primary cultured theca cells derived from PCOS patients. In both H295R cells and primary cultured theca cells, the BM-hMSC secretome inhibited the production of steroids, inflammation, and androgen synthesis 25 , 27 .…”

Section: Regenerative Medicine: Stem Cell Therapymentioning

confidence: 99%

Polycystic ovary syndrome: emerging stem cell therapies

Busari,

Tulay

2024

Rev. Assoc. Med. Bras.

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Section: Regenerative Medicine: Stem Cell Therapymentioning

confidence: 99%

Polycystic ovary syndrome: emerging stem cell therapies

Busari,

Tulay

2024

Rev. Assoc. Med. Bras.

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“…Various experimental models have documented the promising role of stem cells in the alleviation of symptoms of PCOS. MSCs could attenuate DHEA-mediated PCOS in mouse [ 98 ] and human theca cells from PCOS patients [ 160 ] by suppression of inflammation via the release of anti-inflammatory cytokines. Igboeli and co-workers [ 159 ] documented that hMSCs could revert and resume the estrus cycle in a drug-induced mouse model of PCOS [ 161 ] ( Figure 1 ).…”

Section: Stem Cell Therapy In Some Known Syndromesmentioning

confidence: 99%

Application of Stem Cell Therapy for Infertility

Saha

Roy

Corbitt

et al. 2021

Cells

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Infertility creates an immense impact on the psychosocial wellbeing of affected couples, leading to poor quality of life. Infertility is now considered to be a global health issue affecting approximately 15% of couples worldwide. It may arise from factors related to the male (30%), including varicocele, undescended testes, testicular cancer, and azoospermia; the female (30%), including premature ovarian failure and uterine disorders; or both partners (30%). With the recent advancement in assisted reproduction technology (ART), many affected couples (80%) could find a solution. However, a substantial number of couples cannot conceive even after ART. Stem cells are now increasingly being investigated as promising alternative therapeutics in translational research of regenerative medicine. Tremendous headway has been made to understand the biology and function of stem cells. Considering the minimum ethical concern and easily available abundant resources, extensive research is being conducted on induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSC) for their potential application in reproductive medicine, especially in cases of infertility resulting from azoospermia and premature ovarian insufficiency. However, most of these investigations have been carried out in animal models. Evolutionary divergence observed in pluripotency among animals and humans requires caution when extrapolating the data obtained from murine models to safely apply them to clinical applications in humans. Hence, more clinical trials based on larger populations need to be carried out to investigate the relevance of stem cell therapy, including its safety and efficacy, in translational infertility medicine.

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