2022
DOI: 10.1016/j.tibtech.2021.10.009
|View full text |Cite
|
Sign up to set email alerts
|

Towards clinical translation of ‘second-generation’ regenerative stroke therapies: hydrogels as game changers?

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
4
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 14 publications
(4 citation statements)
references
References 96 publications
0
4
0
Order By: Relevance
“…In chronic cerebral stroke, glial scar tissues form around the cavity and the cortex often collapses. [ 39 ] In the mice that received transplantation without the cocktail, the cortex collapsed and few or no GFP+ cells were present at 30 days after transplantation ( Figure ). Strong glial reaction was present in and surrounding the ischemic site, as evidenced by strong staining for a microglial marker Iba1 and an astrocyte marker GFAP (Figure 3a,b).…”
Section: Resultsmentioning
confidence: 99%
“…In chronic cerebral stroke, glial scar tissues form around the cavity and the cortex often collapses. [ 39 ] In the mice that received transplantation without the cocktail, the cortex collapsed and few or no GFP+ cells were present at 30 days after transplantation ( Figure ). Strong glial reaction was present in and surrounding the ischemic site, as evidenced by strong staining for a microglial marker Iba1 and an astrocyte marker GFAP (Figure 3a,b).…”
Section: Resultsmentioning
confidence: 99%
“…Alginates were previously considered scaffolds or drug delivery systems for nerve tissue engineering [ 15 , 16 , 17 , 18 ]. Moreover, alginate hydrogels were shown to enhance the survival of transplanted cells and improve outcomes in animal models of cardiac infarction [ 19 ], hind limb ischemia [ 20 ], and spinal cord injury [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
“…To date, efforts at promoting regeneration in the brain after stroke have achieved limited success. Hydrogels have garnered interest in this arena because of their ability to provide a scaffold for the delivery of potential regenerative therapeutics such as stem cells . However, a significant gap persists in identifying functional materials for modifying innate neuroplasticity.…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogels have garnered interest in this arena because of their ability to provide a scaffold for the delivery of potential regenerative therapeutics such as stem cells. 20 However, a significant gap persists in identifying functional materials for modifying innate neuroplasticity. Electrical stimulation can influence cell proliferation, differentiation, migration, and integration, 21 and experimental studies with noninvasive transcranial direct current stimulation show promise for improving functional recovery after stroke.…”
Section: ■ Introductionmentioning
confidence: 99%