Towards clinically translatable in vivo nanodiagnostics

Park, Seung Min; Aalipour, Amin; Vermesh, Ophir; Yu, Jung Ho

doi:10.1038/natrevmats.2017.14

Cited by 289 publications

(226 citation statements)

References 211 publications

(225 reference statements)

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“…Synergistic integration of these factors may offer promising approaches in fabricating low-toxicity and high-performance CAs that are amenable to clinical translation which will eventually benefit patients. 18 Efficient systemic delivery of CAs to the targeted tissues is of utmost importance for accurate and sensitive detection by MRI, which can include passive accumulation of elaborately synthesized NPs to maximize enhanced permeability and retention (EPR) effect, as well as active targeting of NPs via various ligands such as antibodies, antibody fragments, peptides, small molecules, and proteins. The impacts of nanoparticle size, surface modification, and shape on proton relaxation have been well studied, while their relationship with the EPR effect remains to be further elucidated.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…These characteristics have caused NPs to emerge as promising candidates for next-generation imaging CAs. 18 …”

Section: Introductionmentioning

confidence: 99%

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Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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“…Nanotechnology has attracted great attention for cancer therapy in recent decades, because of the unique physicochemical properties of nanomaterials. Despite the explosive growth of research on nanotechnology‐based anticancer methods, the targeting efficiency, therapeutic outcome, and clinical translation of these nanoplatforms are far from satisfactory . Therefore, a deeper understanding of the complex biosystem and nano–bio interactions is required.…”

Section: Ferroptosis Inducers For Cancer Therapymentioning

confidence: 99%

Recent Progress in Ferroptosis Inducers for Cancer Therapy

et al. 2019

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Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis‐inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.

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“…However, this technique limits the location of inspected and treated cells of internal organs near the surfaces only. The emerging trend to overcome the light penetration problem is development of implantable biomedical optical chips . This new generation of biophotonic lab‐on‐chips encompassing both integrated optical and bioelectronic circuits can be exploited in a human body for a long period of time toward diagnosis, therapeutics, surgery and health monitoring .…”

Section: Biomedical Integrated Optics and Related Materialsmentioning

confidence: 99%

Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

Apter

Lapshina

Handelman

et al. 2018

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Optical waveguiding phenomena found in bioinspired chemically synthesized peptide nanostructures are a new paradigm which can revolutionize emerging fields of precise medicine and health monitoring. A unique combination of their intrinsic biocompatibility with remarkable multifunctional optical properties and developed nanotechnology of large peptide wafers makes them highly promising for new biomedical light therapy tools and implantable optical biochips. This Review highlights a new field of peptide nanophotonics. It covers peptide nanotechnology and the fabrication process of peptide integrated optical circuits, basic studies of linear and nonlinear optical phenomena in biological and bioinspired nanostructures, and their passive and active optical waveguiding. It is shown that the optical properties of this generation of bio-optical materials are governed by fundamental biological processes. Refolding the peptide secondary structure is followed by wideband optical absorption and visible tunable fluorescence. In peptide optical waveguides, such a bio-optical effect leads to switching from passive waveguiding mode in native α-helical phase to an active one in the β-sheet phase. The found active waveguiding effect in β-sheet fiber structures below optical diffraction limit opens an avenue for the future development of new bionanophotonics in ultrathin peptide/protein fibrillar structures toward advanced biomedical nanotechnology.

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Towards clinically translatable in vivo nanodiagnostics

Cited by 289 publications

References 211 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

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