Towards closed-loop neuromodulation: a wireless miniaturized neural implant SoC

Abstract

This work reports a platform technology toward the development of closed-loop neuromodulation. A neural implant based on the SoC developed in our laboratory is used as an example to illustrate the necessary functionalities for the efficacious implantable system. We also present an example of using the system to investigate the epidural stimulation for partial motor function recovery after spinal cord injury in a rat model. This hardware-software co-design tool demonstrate its promising potential towards an effective closed-loop neuromodulation for various biomedical applications.

A Wireless Implantable System for Facilitating Gastrointestinal Motility

“…In order to ensure effective and safe intestinal stimulation, the experiment protocol was designed as follows: 1) The charge injection limit and impedance of the electrode–tissue interface were first characterized using cyclic voltammetry (CV) and two different impedance-measurement methods. This provides a guideline for a safe stimulation protocol that avoids any electrochemical tissue-damaging reaction in the electrode–tissue interface [26]. 2) An acute in vivo test using the electrode array was then performed to investigate the stimulation protocol that is also electrochemically safe for facilitating intestinal motility.…”