Towards construction of a canine linkage map: Establishment of 16 linkage groups

Lingaas, Frode; Sørensen, A.; Juneja, Rajnish; Johansson, S. B. K.; Fredholm, Merete; Winterø, A. K.; Sampson, Jeffrey R.; Mellersh, Cathryn S.; Curzon, Arie Y; Holmes, Nigel G.; Binns, M. M.; Dickens, H. F.; Ryder, Edward; Gerlach, John; Bäumle, E.; Dolf, G.

doi:10.1007/s003359900393

Cited by 75 publications

(47 citation statements)

References 17 publications

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“…The current linkage map is built upon the success of previous efforts (Lingaas et al 1997;Mellersh et al 1997;Dolf 1999;Langston et al 1999;Neff et al 1999); however, those maps were constructed with ,600 markers and lack the coverage, precision, and accuracy needed to optimize linkage analysis and subserve LD mapping (Dukes-McEwan and Jackson 2002). A comprehensive map would enhance genetic analysis in several ways.…”

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confidence: 99%

A Comprehensive Linkage Map of the Dog Genome

et al. 2010

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We have leveraged the reference sequence of a boxer to construct the first complete linkage map for the domestic dog. The new map improves access to the dog's unique biology, from human disease counterparts to fascinating evolutionary adaptations. The map was constructed with $3000 microsatellite markers developed from the reference sequence. Familial resources afforded 450 mostly phase-known meioses for map assembly. The genotype data supported a framework map with $1500 loci. An additional $1500 markers served as map validators, contributing modestly to estimates of recombination rate but supporting the framework content. Data from $22,000 SNPs informing on a subset of meioses supported map integrity. The sex-averaged map extended 21 M and revealed marked region-and sex-specific differences in recombination rate. The map will enable empiric coverage estimates and multipoint linkage analysis. Knowledge of the variation in recombination rate will also inform on genomewide patterns of linkage disequilibrium (LD), and thus benefit association, selective sweep, and phylogenetic mapping approaches. The computational and wet-bench strategies can be applied to the reference genome of any nonmodel organism to assemble a de novo linkage map.

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confidence: 99%

A Comprehensive Linkage Map of the Dog Genome

et al. 2010

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“…Cartographie du génome canin Les travaux sur la génétique canine, utilisant les méthodes de la génétique moléculaire, ont en réalité débuté il y a peu de temps [27,28]. Dès 1995, intéressée par la puissance du modèle, notre équipe a développé les outils moléculaires nécessaires à la construction d'une carte du génome canin par la méthode des hybrides d'irradiation (RH) [29].…”

Section: Analyse Structurale Du Génome Caninunclassified

Le chien, un modèle pour la génétique des mammifères

2004

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“…Since then, the number of microsatellite markers has grown exponentially in man, mice and some other important species (44). For the dog, the genome map is now rapidly advancing with several hundred markers becoming available the last two years (43,48,55,90). The polymorphic DNA markers are typed in families of dogs and the inheritance pattern of the alleles of each marker is followed (Figure 2).…”

Section: Modern Genetic Analysis For Locomotion Disordersmentioning

confidence: 99%

Bone disorders in the dog: A review of modern genetic strategies to find the underlying causes

Everts

Hazewinkel

Rothuizen

et al. 2000

Veterinary Quarterly

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SUMMARYIn man, the genetic defects of more than 600 inherited diseases, of which at least 150 skeletal diseases, have been identified as is the chromosomal location for approximately 7000 genes. This rapid progress has been made possible by the generation of a genetical and physical map of the human genome. There is no reason to believe that for the dog not a similar development may occur. This review is therefore focussed on the use of novel tools now available for comparative molecular genetic studies of skeletal dysplasias in the dog. Because the genomes of mammals at the subchromosomal level are very well conserved, likely candidate disease genes known from other species might be considered. In this review, formation of the bones and the most important canine disorders of the skeleton influencing locomotion will be discussed first. The canine disorders discussed are canine hip dysplasia, the three different forms of elbow dysplasia (fragmented coronoid process, ununited anconeal process, osteochondrosis dissecans and incongruency) and dwarfism. Where possible a link is made with similar diseases in man or mouse. Then, the molecular biological tools available to analyse the genetic defect will be reviewed and some examples discussed.

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Towards construction of a canine linkage map: Establishment of 16 linkage groups

Cited by 75 publications

References 17 publications

A Comprehensive Linkage Map of the Dog Genome

A Comprehensive Linkage Map of the Dog Genome

Le chien, un modèle pour la génétique des mammifères

Bone disorders in the dog: A review of modern genetic strategies to find the underlying causes

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