Towards designing environmentally safe ionic liquids: the influence of the cation structure

Sosnowska, Anita; Barycki, Maciej; Zaborowska, Monika; Rybinska, Anna; Puzyn, Tomasz

doi:10.1039/c4gc00526k

Cited by 61 publications

(48 citation statements)

References 59 publications

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“…Based on its unique properties, ILs have been used extensively in areas of synthesis (Hernández-Fernández et al, 2010), catalysis (Zhang, 2013), analysis (Sun and Armstrong, 2010), and separation (Blahušiak et al, 2011;Chowdhury et al, 2010;Han and Armstrong, 2007). Furthermore, ILs are regarded as "designer solvents" as their polarity, viscosity, hydrophobicity, selectivity toward target compounds can be changed by combining different anions and cations (Huddleston et al, 2001;Larsen et al, 2000;Sosnowska et al, 2014), so they have been successfully applied for extraction of alkaloids (Cao et al, 2009), terpenoids (Lin et al, 2013), flavonoids (Bi et al, 2013), phenolic acids (Du et al, 2009) and other value-added compounds (Liu et al, 2012;Ma et al, 2011;Severa et al, 2013) from natural sources. During last few years, ILs-based extraction methods have been developed, among which ILs-based MAE and UAE seem to be superior in the view of experimental operation, economic expense, and extraction efficiency .…”

Section: Introductionmentioning

confidence: 99%

Optimization of ionic liquid based ultrasonic assisted extraction of antioxidant compounds from Curcuma longa L. using response surface methodology

Wang

Liang

et al. 2015

Industrial Crops and Products

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Section: Introductionmentioning

confidence: 99%

Optimization of ionic liquid based ultrasonic assisted extraction of antioxidant compounds from Curcuma longa L. using response surface methodology

Wang

Liang

et al. 2015

Industrial Crops and Products

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“…PM3 and PM6 [32,33]. By analysing descriptors such as radial distribution functions (RDFs), geometry, and topology, the methodological drawbacks of PM7 tend to vanish, giving results of similar quality as much more expensive DFT methods [34][35][36], why it also has been used for computations of Li + -solvent cluster dynamics [37,38].…”

Section: Introductionmentioning

confidence: 99%

Solvation structure in dilute to highly concentrated electrolytes for lithium-ion and sodium-ion batteries

Flores

Åvall

Jeschke

et al. 2017

Electrochimica Acta

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The solvation structure of several lithium and sodium based electrolytes are explored as a function of salt concentration over a wide range via a detailed PM7 computational study.The cation coordination shells are found to be well-defined and solvent rich for dilute electrolytes, while disordered and anion rich for the more concentrated electrolytes. The Nabased electrolytes display larger cation coordination shells with a more pronounced presence of fluorine as compared to the Li-based electrolytes. The origins of the structural differences are discussed as well as their consequences for properties of battery electrolytes and battery usage -especially targeting the current large interest in highly concentrated electrolytes.

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“…Unfortunately, many publications are conflicted on the specific structural arrangements that impart toxicity to ILs. Recent studies point to elevated toxicity as being primarily affected by cation size or branching [128], specific cation species [129], increased lengths or branching of cation alkyl chains [130], cation aromaticity [130, 131], lipophilicity, surfactant behavior [132], or anion species [131]. Clearly, an improved knowledge of the molecular toxicity characteristics of ILs can help inform the design of greener, less toxic and more benign IL technologies.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of ionic liquid literature and toxicology

et al. 2016

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A meta-analysis was conducted to compare the total amount of ionic liquid (IL) literature (n = 39,036) to the body of publications dealing with IL toxicity (n = 213) with the goal of establishing the state of knowledge and existing information gaps. Additionally, patent literature pertaining to issued patents utilizing ILs (n = 3,358) or dealing with IL toxicity (n =112) were analyzed. Total publishing activity and patent count served to gauge research activity, industrial usage and toxicology knowledge of ILs. Five of the most commonly studied IL cations were identified and used to establish a relationship between toxicity data and potential of commercial use: imidazolium, ammonium, phosphonium, pyridinium, and pyrrolidinium. Toxicology publications for all IL cations represented 0.55% ± 0.27% of the total publishing activity; compared with other industrial chemicals, these numbers indicate that there is still a paucity of studies on the adverse effects of this class of chemical. Toxicity studies on ILs were dominated by the use of in vitro models (18%) and marine bacteria (15%) as studied biological systems. Whole animal studies (n = 87) comprised 31% of IL toxicity studies, with a subset of in vivo mammalian models consisting of 8%. Human toxicology data were found to be limited to in vitro analyses, indicating substantial knowledge gaps. Risks from long-term and chronic low-level exposure to ILs have not been established yet for any model organisms, reemphasizing the need to fill crucial knowledge gaps concerning human health effects and the environmental safety of ILs. Adding to the existing knowledge of the molecular toxicity characteristics of ILs can help inform the design of greener, less toxic and more benign IL technologies.

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Towards designing environmentally safe ionic liquids: the influence of the cation structure

Abstract: The Toxicity Ranking Index for ionic liquids based on the structural similarity of Cations (TRIC), based on data from different toxicological tests.

Cited by 61 publications

References 59 publications

Optimization of ionic liquid based ultrasonic assisted extraction of antioxidant compounds from Curcuma longa L. using response surface methodology

Optimization of ionic liquid based ultrasonic assisted extraction of antioxidant compounds from Curcuma longa L. using response surface methodology

Solvation structure in dilute to highly concentrated electrolytes for lithium-ion and sodium-ion batteries

Meta-analysis of ionic liquid literature and toxicology

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