Towards earlier diagnosis and treatment of disorders of the brain

Fluid–structure interaction for highly complex, statistically defined, biological media: Homogenisation and a 3D multi-compartmental poroelastic model for brain biomechanics

“…It is useful at this stage to describe a field of application of the above class of methodologies, namely biomechanics and in particular the biomechanics of brain diseases. Brain disorders such as developmental and neurodegenerative diseases represent an enormous healthcare burden, not only in terms of human distress, but also economic cost (in Europe, this figure approaches 1 trillion euros (Di Luca et al, 2018)). Cognition is a group of mental processes which include memory, attention, learning, decision making, problem solving, language processing and executive functions.…”

Blood-Brain Delivery Methods Using Nanotechnology

“…Brain diseases, including brain cancer, Alzheimer’s disease, Parkinson’s disease, stroke, and multiple sclerosis, are some of the most prevalent diseases, which are becoming a great concern due to the increase in elderly population [1]. These disorders may be caused by genetic and environmental factors, pathologies in processes involving protein aggregation which lead to neurodegeneration or dysregulation of the immune process, or abnormalities regarding the development and function of the brain [2]. However, compared to other areas of an organism, the treatment for brain diseases is presently unsuccessful mostly due to the complexity of the brain.…”

Neuronanomedicine: An Up-to-Date Overview

“…Due to the increase in elderly populations, the prevalence of these diseases is becoming a great concern [5]. Neurological pathologies are characterized by processes involving protein aggregation which subsequently lead to neurodegeneration or dysregulation of immune mechanisms, or by the progressive loss of neuronal structure and function, associated with abnormalities in brain development and function and neuronal death [6,7]. However, diagnosis, management, and monitoring strategies for neurological disorders are currently unsuccessful mostly due to the complexity of the nervous system [8,9].…”