Towards edible ionic liquids - cholinium taurate

Tot, Aleksandar; Panić, Jovana; Papović, Snežana; Gadžurić, Slobodan; Četojević-Simin, Dragana

doi:10.2298/jsc190413047v

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…The syntheses of cholinium lactate ([Ch][Lac]), cholinium nicotinate ([Ch][Nia]), and cholinium taurate ([Ch][Tau]) were performed according to previously described protocols. Cholinium pyruvate ([Ch][Pyr]) was synthesized in this work for the first time by acid–base titration.…”

Section: Methodsmentioning

confidence: 99%

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Valorization of Expired Energy Drinks by Designed and Integrated Ionic Liquid-Based Aqueous Biphasic Systems

Dimitrijević

Tavares

Almeida

et al. 2020

ACS Sustainable Chem. Eng.

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Expired energy drinks are rich in bioactive value-added compounds that can be recovered and reused in order to valorize food waste within a circular economy perspective. However, to accomplish such requirements, it is necessary to develop sustainable extraction and recovery processes, which must consist of decreasing the number of steps required or developing integrated strategies. In this work, novel aqueous biphasic systems (ABS) composed of ionic liquids (ILs) and a biocompatible polymer polypropylene glycol (400 g·mol–1, PPG 400) were studied for the simultaneous extraction and recovery of three value-added compounds, namely, caffeine, taurine, and niacin, from expired energy drinks. ILs were designed and synthesized in order to have similar anions to the target compounds, thus allowing enhanced selectivity and biological activity, while avoiding an extra step of separation of these high-value compounds from the IL-rich phase. To this end, cholinium-based ILs comprising the anions lactate, pyruvate, taurate, and nicotinate were synthesized, and their cytotoxicity and ecotoxicity credentials were evaluated. Overall, taurine and niacin are majorly enriched in the IL-rich phase, while caffeine preferentially migrates in the majority of the cases toward the PPG-rich phase. However, caffeine also partitions to the IL-rich phase in the ABS formed by cholinium pyruvate or cholinium nicotinate. The ABS formed by cholinium nicotinate and PPG 400 is the best system identified, allowing the almost complete recovery (recovery efficiencies > 82%) of all target compounds into the IL-rich phase in one step. Furthermore, cholinium nicotinate exhibits marginal cytotoxic potential and is harmless from an ecotoxicological point of view. This system is thus a promising platform to simultaneously extract, recover, and reuse value-added compounds from expired energy drinks without the need of removing the IL or recovering the target compounds from the IL-rich phase, thus contributing to a sustainable and circular food economy.

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Section: Methodsmentioning

confidence: 99%

“…IL Synthesis. The syntheses of cholinium lactate ([Ch][Lac]), 40 cholinium nicotinate ([Ch][Nia]), 41 and cholinium taurate ([Ch]-[Tau]) 42 were performed according to previously described protocols. was addressed in the human colon epithelial cell line (Caco-2).…”

Section: ■ Introductionmentioning

confidence: 99%

Valorization of Expired Energy Drinks by Designed and Integrated Ionic Liquid-Based Aqueous Biphasic Systems

Dimitrijević

Tavares

Almeida

et al. 2020

ACS Sustainable Chem. Eng.

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“…The structural characterization of the [Car][Tau] ILs was carried out using FTIR and NMR spectra. The FTIR spectra of the [Car][Tau] ILs (Figure S1c,d) showed absorption bands corresponding to the −OH group at 3331 cm –1 , −SO 3 group at 1193 cm –1 , and −NH 2 group at 1619 cm –1 . , …”

Section: Resultsmentioning

confidence: 99%

“…Taurine (Tau) is one of the most abundant free amino acids in the human body and is an important bioactive substance in the human body. Tau does not occur in the composition of body protein, but can effectively regulate the normal physiological activities of the human body; its impact on human health will extend to the whole life cycle. − Therefore, Tau has a variety of physiological and chemical activities and is closely related to cell proliferation and apoptosis. Tau can be used as a marker of tumorigenesis and early diagnosis, which is of high significance for the prevention of tumors.…”

Section: Introductionmentioning

confidence: 99%

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Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity

Lü

et al. 2021

ACS Sustainable Chem. Eng.

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Tumor is one of the most serious forms of abnormal growth that endangers human health today; its morbidity and mortality are both increasing every year. Most of the antitumor drugs used currently cannot be absorbed well by the human body because of their poor solubility and low bioavailability. Therefore, the prevention and treatment of tumors are still of high significance. These challenges can be addressed by the use of ionic liquids (ILs). Half of the antitumor drugs currently in the market are salts linked together by ILs. Compared to the solid form of the drug, the salt that is liquid at room temperature or body temperature shows good solubility, absorption, and stability. Therefore, in this study, we combined taurine with antitumor activity and alkaloids with biological activity (L-(−)-carnitine or betaine) to produce IL salts possessing the merits of both these components to develop an efficient and cost-effective drug delivery system for tumor treatment. Taurine-based ILs can deliver proteins such as insulin or dextran, which are promising drug delivery carriers. In vitro experiments showed that the taurine-based IL exhibited good biocompatibility, non-toxicity, and antitumor activity. Compared to the blank group, the proliferation inhibition rate of human colon adenocarcinoma cells (Caco-2) treated with different concentrations of taurine-based ILs increased significantly. The inhibitory effect of the taurine-based IL on Caco-2 cell proliferation became more pronounced with an increase in its concentration and the treatment time. Moreover, the results suggested that the combination of taurine-based ILs and chemotherapy drugs can improve the efficacy of chemotherapy drugs and reduce their adverse reactions. Interestingly, taurine-based ILs can inhibit the growth of tumor cells by inducing apoptosis in tumor cells after 4 h. This demonstrates the immense potential of taurine-based ILs in inhibiting the growth of tumor cells.

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The impact of water and ionic liquid on the structure and stability of biomolecules

Palanisamy¹,

Rubavathy²,

Prakash³

2024

Encyclopedia of Solid-Liquid Interfaces

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Towards edible ionic liquids - cholinium taurate

Cited by 7 publications

References 32 publications

Valorization of Expired Energy Drinks by Designed and Integrated Ionic Liquid-Based Aqueous Biphasic Systems

Valorization of Expired Energy Drinks by Designed and Integrated Ionic Liquid-Based Aqueous Biphasic Systems

Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity

The impact of water and ionic liquid on the structure and stability of biomolecules

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