Towards ending TB: civil community engagement in a rural area of Senegal: results, challenges and future proposal

Riccardi, Niccolò; Alagna, Riccardo; Motta, Ilaria; Ferrarese, Maurizio; Castellotti, Paola; Nicolini, Laura Ambra; Diaw, Mama Moussa; Ndiaye, Mamoudou; Cirillo, Daniela María; Codecasa, Luigi; Besozzi, Giorgio

doi:10.1080/23744235.2019.1572920

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…Although TB-HIV coinfection has represented in the last decades a significant problem in Eastern Europe, Asia and the Americas, the main victim of this syndemic, according with the definition of "synergistic epidemic" of Merrill Singer, has been Africa and particularly Sub-Saharan Africa, where a recent meta-analysis reported a decrease from 33.7% before 2000 to 25.7% after 2010, thanks to the strengthening of HIV prevention and treatment programmes [14][15][16].…”

Section: The Beginning Of a New Pandemicmentioning

confidence: 99%

HIV and tuberculosis: A historical perspective on conflicts and challenges

et al. 2020

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Section: The Beginning Of a New Pandemicmentioning

confidence: 99%

HIV and tuberculosis: A historical perspective on conflicts and challenges

et al. 2020

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Section: Introductionmentioning

confidence: 99%

“…10 Community-level interventions that aim to address social and economic factors of non-adherence have also shown promising results on improving treatment success and decreasing loss to follow-up. 11 The introduction and nationwide coverage of TB diagnostic and treatment services utilizing DOT in Armenia, in 1990 and 2002 respectively, was an impactful step in TB management in the country and led to a decline in TB burden between 2004 and 2018. 2,12 TB incidence and mortality rates declined by 2.3 and by 3.2 times, respectively, between 2005-2018.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Treatment Adherence Among Drug-Sensitive Tuberculosis (DS-TB) Patients in Armenia: A Qualitative Study

Grigoryan¹,

McPherson²,

Harutyunyan³

et al. 2022

PPA

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Purpose Despite the availability of effective treatment, tuberculosis (TB) is still one of the leading causes of mortality around the globe. Poor adherence to treatment challenges TB management both globally and locally. Proper adherence to treatment contributes to successful outcomes and prevents the development of drug-resistant forms of TB. Patients and Methods We conducted a qualitative study to identify and describe the factors that facilitated treatment adherence among drug-sensitive TB (DS-TB) patients in Armenia. Sixteen in-depth interviews (IDIs) with former DS-TB patients, two IDIs with family members of former DS-TB patients, and a focus group discussion with healthcare providers who manage DS-TB patients were conducted. The educational and ecological assessment component of the PRECEDE-PROCEED model was applied as a conceptual framework to guide the interview content and data analysis. Results Former patients’ awareness of TB and its treatment, beliefs about TB, trust in TB healthcare providers, and a sense of responsibility were the most common factors that predisposed them to complete the treatment. Support received from providers, family, and friends, a desire to avoid TB-associated stigma, and good tolerance of TB medications were the main reinforcing factors. Enabling factors included a relatively simple regimen of TB treatment and accessibility and affordability of TB services. Conclusion The findings of the study provide new perspectives on factors that facilitate adherence to long-term therapies, such as TB. Interventions that aim to invoke a patient’s sense of responsibility and positive beliefs about TB as well as engage families might promote the successful completion of treatment.

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“…9,12 In addition, there is also a lack of TB knowledge in the health system. 13 The clinical features of TB cases are similar to those of other chest diseases, and health care workers at the community level may not be able to diagnose TB in a timely manner. 14,15 One survey showed that 84.7% of new TB cases were diagnosed after an average of 3.6 misdiagnoses (SD: 2.4) in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

Cut-off Points of Treatment Delay to Predict Poor Outcomes Among New Pulmonary Tuberculosis Cases in Dalian, China: A Cohort Study

Ji¹,

Xu²,

Wu³

et al. 2021

IDR

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Purpose: Despite increasing literature on the association between treatment delay and outcomes, cut-off point (1 month or median) selection in almost all studies for treatment delay is too subjective. This study explored more scientific cut-off points of treatment delay for poor treatment outcomes and death at the clinical level. Patients and Methods: A total of 18,100 newly confirmed pulmonary tuberculosis (TB) cases in Dalian, China were used in the final analysis. A 3-knotted restricted cubic spline (RCS) fitted for Cox proportional hazard regression models is used to analyse the effects of cut-off points of treatment delay on incident poor treatment outcomes. To explore the moderating effects of age, gender and diabetes, we added the interaction terms of these moderating variables and treatment delay to Cox proportional hazard regression models. Results:The median time of treatment initiation was 30 days (IQR: 14-59 days). The risk of incident poor treatment outcomes increased when the time was greater than cut-off point 1 (53 days; adjusted HR: 1.26; 95% CI: 1.00-1.60) of treatment delay, and the risk of incident death events increased when the time was greater than cut-off point 2 (103 days; adjusted HR: 1.56; 95% CI: 1.00-2.44) of delay. In addition, treatment delay was associated with an increased risk of incident poor treatment outcomes and death, and older age, male sex, and diabetes may increase the risk of treatment delay for poor outcomes. Conclusion:This study is the first to identify scientific cut-off points of treatment delay for poor treatment outcomes and death, and this method of exploration should be popularized. In addition, the knowledge of tuberculosis must be spread to every adult. Moreover, the tuberculosis diagnosis level of community level health workers should be enhanced.

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Towards ending TB: civil community engagement in a rural area of Senegal: results, challenges and future proposal

Cited by 8 publications

References 9 publications

HIV and tuberculosis: A historical perspective on conflicts and challenges

HIV and tuberculosis: A historical perspective on conflicts and challenges

Factors Influencing Treatment Adherence Among Drug-Sensitive Tuberculosis (DS-TB) Patients in Armenia: A Qualitative Study

Cut-off Points of Treatment Delay to Predict Poor Outcomes Among New Pulmonary Tuberculosis Cases in Dalian, China: A Cohort Study

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