Towards enhancement of gas–liquid mass transfer in bioelectrochemical systems: Validation of a robust CFD model

Karimi, Mohsen; Widén, Tove; Nygård, Yvonne; Olsson, Lisbeth; Ström, Henrik

doi:10.1002/bit.27871

Cited by 4 publications

(4 citation statements)

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“…Interestingly, we found that the difference in productivity owing to high dissolved oxygen decreased as fermentation progressed, as shown in Figure 3B . Therefore, we speculate that, under high dissolved oxygen conditions, the gas-liquid transfer efficiency controlled by the gas film does not affect the ability of the strain to produce acid ( Karimi et al, 2021 ), but rather its ability to take up oxygen. Fortunately, previous studies have shown that oxygen vectors can enhance the uptake of oxygen by microorganisms ( Rols and Goma, 1989 ), thereby enhancing the growth and metabolism of the strain, and further increasing the production of secondary metabolites ( You et al, 2021 ).…”

Section: Resultsmentioning

confidence: 95%

Section: Equipment Performance Of Oxygen-enhanced Bioreactorsmentioning

confidence: 85%

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Productivity enhancement in L-lysine fermentation using oxygen-enhanced bioreactor and oxygen vector

Wang

Zhao

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: L-lysine is a bulk product. In industrial production using high-biomass fermentation, the high density of bacteria and the intensity of production require sufficient cellular respiratory metabolism for support. Conventional bioreactors often have difficulty meeting the oxygen supply conditions for this fermentation process, which is not conducive to improving the sugar-amino acid conversion rate. In this study, we designed and developed an oxygen-enhanced bioreactor to address this problem.Methods: This bioreactor optimizes the aeration mix using an internal liquid flow guide and multiple propellers.Results: Compared with a conventional bioreactor, it improved the kLa from 367.57 to 875.64 h-1, an increase of 238.22%. The results show that the oxygen supply capacity of the oxygen-enhanced bioreactor is better than that of the conventional bioreactor. Its oxygenating effect increased the dissolved oxygen in the middle and late stages of fermentation by an average of 20%. The increased viability of Corynebacterium glutamicum LS260 in the mid to late stages of growth resulted in a yield of 185.3 g/L of L-lysine, 74.57% conversion of lysine from glucose, and productivity of 2.57 g/L/h, an increase of 11.0%, 6.01%, and 8.2%, respectively, over a conventional bioreactor. Oxygen vectors can further improve the production performance of lysine strains by increasing the oxygen uptake capacity of microorganisms. We compared the effects of different oxygen vectors on the production of L-lysine from LS260 fermentation and concluded that n-dodecane was the most suitable. Bacterial growth was smoother under these conditions, with a 2.78% increase in bacterial volume, a 6.53% increase in lysine production, and a 5.83% increase in conversion. The different addition times of the oxygen vectors also affected the final yield and conversion, with the addition of oxygen vectors at 0 h, 8 h, 16 h, and 24 h of fermentation increasing the yield by 6.31%, 12.44%, 9.93%, and 7.39%, respectively, compared to fermentation without the addition of oxygen vectors. The conversion rates increased by 5.83%, 8.73%, 7.13%, and 6.13%, respectively. The best results were achieved by adding oxygen vehicles at the 8th hour of fermentation, with a lysine yield of 208.36 g/L and a conversion rate of 83.3%. In addition, n-dodecane significantly reduced the amount of foam produced during fermentation, which is beneficial for fermentation control and equipment.Conclusion: The new oxygen-enhanced bioreactor improves oxygen transfer efficiency, and oxygen vectors enhance the ability of cells to take up oxygen, which effectively solves the problem of insufficient oxygen supply during lysine fermentation. This study provides a new bioreactor and production solution for lysine fermentation.

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Section: Resultsmentioning

confidence: 95%

Section: Equipment Performance Of Oxygen-enhanced Bioreactorsmentioning

confidence: 85%

Productivity enhancement in L-lysine fermentation using oxygen-enhanced bioreactor and oxygen vector

Wang

Zhao

et al. 2023

Front. Bioeng. Biotechnol.

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“…A more general Sh correlation needs to consider the hydrodynamics. 333 Due to the deformation of bubbles, oscillations may occur and lead to additional contributions to the local mass transfer rate. The oscillation of bubbles is related to bubble volume, the fluid properties and column geometry.…”

Section: Gas−liquid Mass Transfer Processmentioning

confidence: 99%

“…This formula has a similar dependence on the hydrodynamics, bubble diameter, and Sc number. A more general Sh correlation needs to consider the hydrodynamics …”

Section: Gas–liquid Mass Transfer Processmentioning

confidence: 99%

Computational Fluid Dynamics Based Modeling of Gas Absorption Process: A State-of-the-Art Review

Liu,

Wang,

Cai

et al. 2024

Ind. Eng. Chem. Res.

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The effective removal of gas phase species relies on effective gas liquid hydrodynamic contact coupling with fast chemical reaction rates. To promote mass transfer rate and the development of reagents, computational fluid dynamic modeling has long been recognized as an effective methodology for the quantification of physical and chemical parameters. The simulation of the gas liquid process involves the coupling of models including multiphase flow, turbulence, interfacial forces, mass transfer, and chemical reactions. The selection of suitable models according to practical applications has been challenging. In terms of multiphase flow, volume of fraction, Euler−Euler, and Euler−Lagrange approaches are discussed. With regard to turbulence, direct numerical simulation, large eddy simulation, and Reynolds averaged Navier−Stokes approach are compared. With respect to interfacial forces, the dominance of drag, lift, virtual mass, wall lubrication, and turbulent dispersion forces for different situations are obtained. In terms of mass transfer, the development and applications of film model, dimensionless analysis, penetration model, and surface renewal model are discussed. Different methodologies to enhance mass transfer include improvement of equipment structure, addition of nanofluid, and exposure to an energy field are summarized. To accelerate the computational process, four methods including the space−time conservation element and solution element model, compartmental model, reduction in dimension, and multiscale approach are discussed. This paper intends to provide a thorough review on the applications of different models to different situations and, in particular, to reveal the restrictions of different models. Overall, this study lays the foundation for future studies on the optimization of scrubbers for large scale practical applications. It also allows a deeper understanding of the interactions of fluid dynamics, mass transfer, and chemical reactions.

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A review on bioelectrochemical systems for emerging pollutants remediation: A computational approaches

Ahmadi

Rezae

Ghosh

et al. 2023

Journal of Environmental Chemical Engineering

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Towards enhancement of gas–liquid mass transfer in bioelectrochemical systems: Validation of a robust CFD model

Cited by 4 publications

References 50 publications

Productivity enhancement in L-lysine fermentation using oxygen-enhanced bioreactor and oxygen vector

Productivity enhancement in L-lysine fermentation using oxygen-enhanced bioreactor and oxygen vector

Computational Fluid Dynamics Based Modeling of Gas Absorption Process: A State-of-the-Art Review

A review on bioelectrochemical systems for emerging pollutants remediation: A computational approaches

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