National governments across Sub-Saharan Africa include climate-smart agriculture (CSA) - context-specific interventions that support resilience, productivity, and climate mitigation-in plans and policies and strategies to jointly address climate change, agricultural production and rural livelihood goals. This paper synthesizes the evidence on field-based CSA management practices generated through ten years of research led by the CGIAR in Tanzania, an agriculturally diverse country in East Africa that has prioritized climate-smart agriculture practices in its climate adaptation strategies. Tanzania provides an illustrative example of how countries can use evidence of impacts, synergies and tradeoffs to prioritize activities for sustainable development.