Towards Foldameric Miniproteins: A Helix‐Turn‐Helix Motif

Ożga, Katarzyna; Drewniak-Świtalska, Magda; Rudzińska-Szostak, Ewa; Berlicki, Łukasz

doi:10.1002/cplu.202100090

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…Foldamers are synthetic molecules that adopt a conformationally ordered state in solution, similarly to biopolymers such as proteins or nucleic acids [ 150 , 151 , 152 ]. Therefore, foldamers gained popularity in light of the possibility of designing molecules in such a way that they have defined functionalities similar to natural macromolecules [ 153 ].…”

Section: Foldamers In Sensingmentioning

confidence: 99%

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

et al. 2022

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Sensors are tools for detecting, recognizing, and recording signals from the surrounding environment. They provide measurable information on chemical or physical changes, and thus are widely used in diagnosis, environment monitoring, food quality checks, or process control. Polymers are versatile materials that find a broad range of applications in sensory devices for the biomedical sector and beyond. Sensory materials are expected to exhibit a measurable change of properties in the presence of an analyte or a stimulus, characterized by high sensitivity and selectivity of the signal. Signal parameters can be tuned by material features connected with the restriction of macromolecule shape by crosslinking or folding. Gels are crosslinked, three-dimensional networks that can form cavities of different sizes and forms, which can be adapted to trap particular analytes. A higher level of structural control can be achieved by foldamers, which are macromolecules that can attain well-defined conformation in solution. By increasing control over the three-dimensional structure, we can improve the selectivity of polymer materials, which is one of the crucial requirements for sensors. Here, we discuss various examples of polymer gels and foldamer-based sensor systems. We have classified and described applied polymer materials and used sensing techniques. Finally, we deliberated the necessity and potential of further exploration of the field towards the increased selectivity of sensory devices.

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Section: Foldamers In Sensingmentioning

confidence: 99%

Shaping Macromolecules for Sensing Applications—From Polymer Hydrogels to Foldamers

et al. 2022

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“… 77 , 78 This rationale was also used to construct the foldameric helix–turn–helix structure. 79 The use of a very rigid turn required a combinatorial calculation of possible spatial arrangements of the secondary structures based on experimental data of the torsions within the helix and the extended structure of the turn. The compactness of the structure was confirmed by 2D NMR.…”

Section: Incorporation Of Noncanonical Amino Acidsmentioning

confidence: 99%

Design and Engineering of Miniproteins

Ożga

Berlicki

2022

ACS Bio Med Chem Au

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The potential of miniproteins in the biological and chemical sciences is constantly increasing. Significant progress in the design methodologies has been achieved over the last 30 years. Early approaches based on propensities of individual amino acid residues to form individual secondary structures were subsequently improved by structural analyses using NMR spectroscopy and crystallography. Consequently, computational algorithms were developed, which are now highly successful in designing structures with accuracy often close to atomic range. Further perspectives include construction of miniproteins incorporating nonnative secondary structures derived from sequences with units other than α-amino acids. Noteworthy, miniproteins with extended structures, which are now feasibly accessible, are excellent scaffolds for construction of functional molecules.

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“…32 Using various approaches, steps were made away from purely α-peptidic backbones, and β-amino acids were introduced in tertiary structures. [33][34][35][36][37][38][39] Some helix bundles from β-peptides 40,41 and oligoureas 42,43 have also been reported.…”

Section: Introductionmentioning

confidence: 99%