Towards
            <i>in vivo</i>
            biosensors for low‐cost protein sensing

Anisha, R.; Ren, Fang; Berger, Paul R.; Casal, Patricia; Theiss, Andrew; Gupta, Samit Kumar; Lee, S.C.

doi:10.1049/el.2012.4283

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…The current magnitude of the ISFET depends on the charge density (concentration) of the analyte molecules on the gate surface. Several studies have reported the Na + detection of graphene-and silicon-based ISFETs [4,5]. The objective of this work is to investigate the effect of the oxygen gas flow rate at room temperature sputtering of ITO thin film on the sensitivity to Na + .…”

mentioning

confidence: 99%

Low‐cost fabrication of indium tin oxide (ITO) FETs for sodium detection in electrolytes and human urine

Gianti

Cho

et al. 2021

Electronics Letters

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Here, robust and low-cost sodium sensors based on the ion-sensitive field-effect transistor (ISFET) are fabricated using indium tin oxide (ITO) thin film. The effect of the presence of oxygen during the sputtering of the ITO thin film is characterized on the sensitivity of sodium ion (Na + ) detection. A sodium ionophore III membrane is applied on the ITO substrate to fabricate ISFET (ITO-ISFET). The results reveal that the increase in the oxygen gas flow rate (0-1 sccm) with a fixed argon flow rate at 20 sccm during sputtering increased the sensitivity of ITO-ISFET to Na + from 15.8 to 100.9 mV/decade. In addition, the proper condition with a nearly Nernstian slope is at 0.4 sccm oxygen flow rate. Furthermore, the experimental results reveal that the sensors exhibit a high sensitivity of 58.5 ± 2.1 mV/decade in a wide range (10 −10 to 10 −1 M). The limit of detection (LOD) of ITO-ISFET is 1.8 nM, which is lower than the minimum allowable Na + level in the human body and urine. Furthermore, the proposed ITO-ISFET has the capability to detect Na + in real human patient urine without any dilution process.

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mentioning

confidence: 99%

Low‐cost fabrication of indium tin oxide (ITO) FETs for sodium detection in electrolytes and human urine

Gianti

Cho

et al. 2021

Electronics Letters

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“…Ramesh et al have recently presented a new sensor fabrication technology where they replaced the silicon dioxide layer with a high quality dielectric made of Al 2 O 3 . 6 In this new configuration, the use of an Al 2 O 3 film instead of the thermally grown SiO 2 allowed them to eradicate the issue of mobile ion interference in the biosensors during protein concentration measurements. Al 2 O 3 was deposited on the surface of the silicon substrate using an atomic layer deposition process, with trimethyl aluminium and water as precursors.…”

Section: Reliable Biosensors For Low-cost Protein Sensingmentioning

confidence: 99%

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et al. 2014

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“…Since nanosensors can interact directly with the most fundamental elements in matter, e.g., atoms and molecules, they can provide ultra-high sensitivity. One of the most promising applications of nanosensors is in vivo biosensing [4], [5], where nanosensors are injected into human body to collect real-time information. Nanosensors can be utilized both to detect well-known diseases at their very early stage as well as to provide new fundamental insights and understanding of biological processes that cannot be observed at the macroscopic level.…”

Section: Introductionmentioning

confidence: 99%

Cooperative Raman Spectroscopy for Real-Time <italic>In Vivo</italic> Nano-Biosensing

Guo

Jornet

Gan

et al. 2017

IEEE Trans.on Nanobioscience

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In the last few decades, the development of miniature biological sensors that can detect and measure different phenomena at the nanoscale has led to transformative disease diagnosis and treatment techniques. Among others, biofunctional Raman nanoparticles have been utilized in vitro and in vivo for multiplexed diagnosis and detection of different biological agents. However, existing solutions require the use of bulky lasers to excite the nanoparticles and similarly bulky and expensive spectrometers to measure the scattered Raman signals, which limit the practicality and applications of this nano-biosensing technique. In addition, due to the high path loss of the intra-body environment, the received signals are usually very weak, which hampers the accuracy of the measurements. In this paper, the concept of cooperative Raman spectrum reconstruction for real-time in vivo nano-biosensing is presented for the first time. The fundamental idea is to replace the single excitation and measurement points (i.e., the laser and the spectrometer, respectively) by a network of interconnected nano-devices that can simultaneously excite and measure nano-biosensing particles. More specifically, in the proposed system a large number of nanosensors jointly and distributively collect the Raman response of nano-biofunctional nanoparticles (NBPs) traveling through the blood vessels. This paper presents a detailed description of the sensing system and, more importantly, proves its feasibility, by utilizing accurate models of optical signal propagation in intra-body environment and low-complexity estimation algorithms. The numerical results show that with a certain density of NBPs, the reconstructed Raman spectrum can be recovered and utilized to accurately extract the targeting intra-body information. Index Terms

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Towards in vivo biosensors for low‐cost protein sensing

Cited by 6 publications

References 4 publications

Low‐cost fabrication of indium tin oxide (ITO) FETs for sodium detection in electrolytes and human urine

Low‐cost fabrication of indium tin oxide (ITO) FETs for sodium detection in electrolytes and human urine

Research highlights

Cooperative Raman Spectroscopy for Real-Time <italic>In Vivo</italic> Nano-Biosensing

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