Contemporary research in the field of technology and production is focused on the intensive development of highly automated --so called intelligent and autonomous devices and systems, for smaller (discretized) production volumes (of products and business --production activities of their realization). This development implies a need to create a new knowledge and change --re-evaluate and upgrade of existing knowledge: project approaches and content related to product, process, and system design, as well as a need to include traditional non-engineering areas such as biology and medicine (neuroscience, anatomy, psychiatry). Regarding products, especially, it is interesting to consider the performance of processes in which deformable objects and sculpture surfaces appear in different industries. Consideration of advanced sensorics and virtual reality (VR) involves the analysis of manual processes [1], as yet the most widespread, and as a basis for better understanding and optimization (stabilization) as well as standardization ("normization") of manual processes [2], thus enabling development of mechatronic devices for automatic process execution.Technology development allows the design and standardization of manual work in human activities which are yet to be observed, especially those of low-volume discrete production, such as in ear, nose and throat (ENT) surgery, particularly endoscopic sinus surgery (ESS). The paper considers the possibilities of developing an approach that would be useful for specific ESS manual work analysis and design and its automation in a future. The consideration includes, beside other aspects, initial steps, such as the traditional work motion capture by camera and experiments by Leap Motion Controller, Perception Neuron 2.0 and Emotiv Epoc+.