Towards improved removal of uremic toxins from human plasma

In vitro assessment of mixed matrix hemodialysis membrane for achieving endotoxin-free dialysate combined with high removal of uremic toxins from human plasma

“…This study revealed that the MMM has low drop in white blood cells and platelet count, low thrombin-antithrombin III-complex (TAT) and complement activation (C5a generation) and causes no hemolysis. In fact, the MMM blood compatibility is comparable to reference commercial dialysis fibers used currently in the clinic [33]. In this study, we investigate the application of MMM for achieving complete removal of endotoxins from dialysate and preventing transfer of endotoxins to the blood compartment while at the same time achieving high removal of uremic toxins from human plasma.…”