Towards intraoperative hyperspectral imaging: design considerations for neurosurgical applications

Intraoperative hyperspectral label-free imaging: from system design to first-in-patient translation

“…To ensure surgical safety and sterility, system maintenance should be straightforward and it should be possible to clean the system’s components effectively using a standard antimicrobial surface wipe (T1). The minimum requirements of HSI camera dimensions and weight are based on the estimates in Shapey et al ( 2018 ) obtained through a prototyping-testing design thinking methodology (Yock et al 2015 ), i.e. a camera smaller than 10 × 10 × 12 cm 3 (T2) and lighter than 1.0 kg (T3).…”

“…In this paper, our contributions are four-fold: (a) by building on our preliminary work (Shapey et al 2018 ), we first present a set of design requirements, including functional and technical requirements, critical for an iHSI system to provide real-time wide-field HSI information for seamless surgical guidance in a highly constrained operating room (OR); (b) we present and evaluate our developed iHSI system against these requirements by considering two state-of-the-art industrial HSI camera systems based on linescan and snapshot imaging technology as further described in section 3.1 ; (c) we perform ex vivo animal tissue experiments in a controlled environment with our proposed iHSI setup to investigate tissue properties using both camera systems; and (d) we report the use of our real-time iHSI system (figure 1 ) during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that this system can be seamlessly integrated into the OR without interrupting the surgical workflow.…”