2012
DOI: 10.3109/10929088.2012.708788
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Towards modeling tumor motion in the deflated lung for minimally invasive ablative procedures

Abstract: A computational model is proposed to demonstrate the feasibility of characterizing the motion of lung tumors caused by respiratory diaphragm forces using a tissue biomechanics approach. Compensating for such motion is very important for developing effective systems of minimally invasive tumor ablative procedures, e.g., Low Dose Rate (LDR) lung brachytherapy. To minimize the effects of respiratory motion, the target lung is almost completely deflated before starting such procedures. However, a significant amoun… Show more

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Cited by 3 publications
(3 citation statements)
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“…Lungs are very soft and their deformation is accompanied by significant volume reduction inside the thoracic cavity, which results in topological changes in the CT image space. The mechanism of pneumothoraxassociated deformation is complex and not mathematically understood, except through simulation studies of animal lungs [4], [9].…”
Section: Introductionmentioning
confidence: 99%
“…Lungs are very soft and their deformation is accompanied by significant volume reduction inside the thoracic cavity, which results in topological changes in the CT image space. The mechanism of pneumothoraxassociated deformation is complex and not mathematically understood, except through simulation studies of animal lungs [4], [9].…”
Section: Introductionmentioning
confidence: 99%
“…Intraoperative deformation due to changes in internal pressure, patient posture, and tool manipulation is a well-known practical registration problem, which must be addressed in the development of intraoperative guidance systems [8–16]. Specifically, in the field of image-based lung modeling, respiratory motion has been the main focus of investigation [17–21]. However, there have been few studies on modeling of the pneumothorax deformation that occurs between the preoperative and intraoperative lung states.…”
Section: Introductionmentioning
confidence: 99%
“…Lungs are very soft organs, and their deformation can induce considerable volume change. The mechanism of pneumothorax deformation is complex and not mathematically understood, except through simulation studies of animal lungs [17, 22]. CT intensity shifts occur in the atelectasis state, where the air content of the lungs is reduced, resulting in changes to CT values and lowering of image contrast, and reduced performance for image-based registration.…”
Section: Introductionmentioning
confidence: 99%