2012 IEEE International Conference on Robotics and Automation 2012
DOI: 10.1109/icra.2012.6225041
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Towards MR-navigable nanorobotic carriers for drug delivery into the brain

Abstract: Magnetic Resonance Navigation (MRN) relies on Magnetic Nanoparticles (MNPs) embedded in microcarriers or microrobots to allow the induction of a directional propelling force by 3-D magnetic gradients. These magnetic gradients are superposed on a sufficiently high homogeneous magnetic field (e.g. the Bo field of a MR scanner) to achieve maximum propelling force through magnetization saturation of the MNPs. As previously demonstrated by our group, such technique was successful at maintaining microcarriers along … Show more

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Cited by 30 publications
(15 citation statements)
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“…Microrobotics is one of the newest research areas in surgical robotics. Microrobots have been proposed for various applications, e.g., arterial plaque removal [10], intravascular drug delivery [124], intraocular drug delivery [125], drug delivery in the brain [126]. A thorough review of state-of-the-art systems can be found in [25].…”
Section: E Untethered Microsurgeons -4 Th Generationmentioning
confidence: 99%
“…Microrobotics is one of the newest research areas in surgical robotics. Microrobots have been proposed for various applications, e.g., arterial plaque removal [10], intravascular drug delivery [124], intraocular drug delivery [125], drug delivery in the brain [126]. A thorough review of state-of-the-art systems can be found in [25].…”
Section: E Untethered Microsurgeons -4 Th Generationmentioning
confidence: 99%
“…Furthermore, previous research also demonstrated that AMF-induced hyperthermia only led to a transient BBB permeability increase in vivo . Their results showed that 0.5 h AMF-induced hyperthermia can increase the BBB permeability transiently and the BBB permeability recovered 2 h after hyperthermia treatment in mice (45). In the present stu dy AMF-induced hyperthermia showed the potential advantages of transiently increased BBB permeability and reduced toxicity compared with conventional hyperthermia, potentially increasing the brain targeting of IONPs and their pharmacotherapeutic efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…78 Newly designed carriers based on magnetic nanoparticles (MNPs) that are characterized by high magnetization saturation have been reported. 79 MNPs were incorporated into a polymer that serves as a transport mediator. It was shown 79 that alternating magnetic field strength excited MNPs, which started to release their energy in the form of heat to the surrounding area.…”
Section: Biological Stimulimentioning
confidence: 99%
“…79 MNPs were incorporated into a polymer that serves as a transport mediator. It was shown 79 that alternating magnetic field strength excited MNPs, which started to release their energy in the form of heat to the surrounding area. Using magnetic resonance to steer and track MNPs, they were propelled to the BBB, where local hyperthermia was achieved after creating an alternating magnetic field that caused temporal disruption of the BBB.…”
Section: Biological Stimulimentioning
confidence: 99%