Towards multimodal cellular imaging: optical and X-ray fluorescence

Graziotto, Marcus E.; Kidman, Clinton J.; Adair, Liam D.; James, Simon A.; Harris, Hugh H.; New, Elizabeth J.

doi:10.1039/d3cs00509g

Cited by 10 publications

(5 citation statements)

References 112 publications

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“…From a methodological point of view, simultaneous measurement of all modalities has particular importance in producing overlay imaging with the same probing spatial resolution. Such integrative multimodal imaging approach is still in its infancy (Callefo et al, 2022;Graziotto et al, 2023). It permits to combine all information to study highly heterogenous systems in a more quantitative manner and with higher sensitivity.…”

Section: Discussionmentioning

confidence: 99%

State-of-the-art multimodal scanning hard X-ray imaging and tomography sheds light at multiple length-scales on biomineralization related processes

Medjoubi,

Benzerara,

Debrie

et al. 2024

Front. Environ. Chem.

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Biomineralization is a widespread process among living organisms, playing a significant role in the formation and preservation of geological structures, biogeochemical cycles, regulation of ocean chemistry, and carbon sequestration. Moreover pathological biomineralization has a huge impact on human health. The growth of biominerals provides a rich area for research at multiple length-scales since they have controlled hierarchical structures from nano-to macroscopic scales. Here, we provide an overview on the potentials of the state-of-the-art scanning hard X-ray imaging and tomography methods developed at the NANOSCOPIUM beamline at Synchrotron Soleil in such studies. Multimodal scanning imaging provides simultaneous information on the elemental composition by X-ray fluorescence (XRF) spectrometry, on the sample morphology by absorption contrast imaging, on the crystalline structure by X-ray diffraction, and on the luminescence characteristics by X-ray Excited Optical Luminescence. As illustrated through diverse research cases about biomineralization in stromatolites and pathological calcification, such a versatile portfolio of X-ray imaging techniques provides unique complementary information to conventional laboratory techniques on biominerals and the underlying mineral precipitation processes.

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Section: Discussionmentioning

confidence: 99%

State-of-the-art multimodal scanning hard X-ray imaging and tomography sheds light at multiple length-scales on biomineralization related processes

Medjoubi,

Benzerara,

Debrie

et al. 2024

Front. Environ. Chem.

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“…While no single imaging method is universally superior, the combination of multiple imaging modalities enables researchers to obtain more comprehensive image information and detailed structural insights [ 371 ]. Employing basic fluorescence imaging as a foundation, and supplementing it with other modalities like CT, MRI, and ultrasound, allows for the synergistic visualization of specific anatomical structures and the tracking and detection of targeted molecules [ 372 ].…”

Section: Image Formationmentioning

confidence: 99%

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Zhang,

Yu,

et al. 2024

Materials Today Bio

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“…In the past few years, several reviews have been published to discuss the progress of dual/multi-modal imaging [ 41 , 42 , 43 , 44 ], due to its advantages in the diagnosis of diseases. However, none of them focused on the AIE type contrast, although they show several advantages, as discussed before.…”

Section: Introductionmentioning

confidence: 99%

Dual/Multi-Modal Image-Guided Diagnosis and Therapy Based on Luminogens with Aggregation-Induced Emission

Zhu,

2024

Molecules

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The combination of multiple imaging methods has made an indelible contribution to the diagnosis, surgical navigation, treatment, and prognostic evaluation of various diseases. Due to the unique advantages of luminogens with aggregation-induced emission (AIE), their progress has been significant in the field of organic fluorescent contrast agents. Herein, this manuscript summarizes the recent advancements in AIE molecules as contrast agents for optical image-based dual/multi-modal imaging. We particularly focus on the exceptional properties of each material and the corresponding application in the diagnosis and treatment of diseases.

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Towards multimodal cellular imaging: optical and X-ray fluorescence

Abstract: This review provides an overview of recent studies where optical and X-ray fluorescence imaging have been performed in combination in multimodal studies of cellular systems.

Cited by 10 publications

References 112 publications

State-of-the-art multimodal scanning hard X-ray imaging and tomography sheds light at multiple length-scales on biomineralization related processes

State-of-the-art multimodal scanning hard X-ray imaging and tomography sheds light at multiple length-scales on biomineralization related processes

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Dual/Multi-Modal Image-Guided Diagnosis and Therapy Based on Luminogens with Aggregation-Induced Emission

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