In this paper, we propose an automated, datadriven and unobtrusive framework to analyze interactional synchrony. We use this information to determine whether interpersonal synchrony can be an indicator of deceit. Our framework includes a robust facial tracking module, an effective expression recognition method, synchrony feature extraction and feature selection methods. These synchrony features are used to learn classification models for the deception recognition. To evaluate our proposed framework, we have conducted extensive experiments on a database of 242 video samples. We validate the performance of each technical module in our framework, and also show that these synchrony features are very effective at detecting deception.