Towards nanomaterials with tubular pores: synthesis and self-assembly of bis-pillar[5]arene

Abstract

Recently, materials obtained using supramolecular chemistry approaches, and, in particular, spatially preorganized macrocyclic compounds, have attracted close attention of the researchers. Pillar[n]arenes are of special interest due to their tubular spatial structure and macrocyclic cavity. A similar tubular structure is retained in the supramolecular packaging of pillar[5]arene crystals, forming pores. In this study, we developed a block synthetic approach for the preparation of bis-pillar[5]arene containing amide groups. The ability of the synthesized bis-pillar[5]arene to form stable self-associates in solvents of different polarity (CHCl3 and CH3OH) was demonstrated by the DLS method. In trichloromethane at concentration of 1·10–3 M, monodisperse associates with average hydrodynamic diameter of 227 nm (PDI = 0.28) are formed; in methanol, stable associates (1·10–6 M) have an average hydrodynamic diameter of 136 nm (PDI = 0.21). The results obtained can be used to create new supramolecular systems, molecular machines, or capture and detect various organic molecules.

Cationic amphiphilic meroterpenoids: synthesis, antibacterial, antifungal and mutagenic activity

“…In recent years, more and more attention has been paid to the development of antimicrobial agents based on natural and semi-synthetic sources [15][16][17][18][19]. Terpenoids represent one of the most extensive and structurally diverse groups of natural compounds [20,21].…”