Towards new approaches to disorders of fear and anxiety

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

“…This is particularly stressful to the patients and represents a significant challenge to compliance rates and therapeutic success. Thus, co-treatment with drugs, which may enhance fear extinction and/or suppress the acute negative affect, may promote exposure therapy (Bitencourt et al 2013;Dias et al 2013;Parsons and Ressler 2013). The search for optimal intervention strategies may benefit from basic research studying the mechanisms of acquisition, consolidation, and extinction of conditioned fear.…”

“…treatment for PTSD (Graham and Milad 2011). It includes confrontation with trauma reminders (exposure therapy) (Dias et al 2013;Kearns et al 2012). This is particularly stressful to the patients and represents a significant challenge to compliance rates and therapeutic success.…”

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

“…This perception often results in an apprehensive mood accompanied by increased arousal and vigilance, which when taken to an extreme persist for extended periods of time (Dias et al, 2013). However, when anxiety becomes overwhelming, it may fall under the classification of an anxiety disorder.…”

Mexican Medicinal Plants Used to Alleviate the Symptoms of Anxiety: Mini-Review

“…Anxiety can also be modeled using both light-enhanced, and dark-enhanced startle paradigms, context conditioning, and by Introduction exploiting the unpredictability of aversive events, such as mild shock [11].…”