Towards Novel HIV-1 Serodiagnostic Tests without Vaccine-Induced Seroreactivity

Lagatie, Ole; Lauwers, Dax; Singh, Harvinder; Vanroye, Fien; Stieh, Daniel J.; Vingerhoets, Johan; Lavreys, Ludo; Oriol-Mathieu, Valérie; Colón, Will; Verhofstede, Chris; Vercauteren, Koen; Van den Bossche, Dorien; Pau, Maria Grazia

doi:10.1128/spectrum.00715-23

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Rapid determination of source patient HIV status provides essential information about the need to initiate or continue PEP. Many tests can be used to assess HIV status, such as rapid assays, third-generation chemiluminescent immunoassays, and fourth-generation combination p24 antigen-HIV antibody tests [25][26][27][28][29][30]. Administration of PEP should not be delayed while waiting for test results.…”

Section: Initial Hiv Infectionmentioning

confidence: 99%

Incidence and Risks of HIV Infection, Medication Options, and Adverse Effects in Accidental Needle Stick Injuries: A Narrative Review

Abadie,

Brown,

Campbell

et al. 2024

Cureus

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Accidental needle sticks can lead to infections, including HIV. As scientists have learned more about HIV and its replicative physiology, identification of target sites and novel medications have been developed. HIV is spread throughout the population through contact with blood, semen, and rectal or vaginal secretions of infected individuals. Therefore, it is important in general for healthcare workers to be aware of its transmission modes and ways to minimize exposure. In this regard, even with hospitals providing education, training, and safety protocols, there is a continued infection spread with HIV, especially by accidental needle sticks. There is also a wide variety of testing that can be used for HIV utilizing different methodologies, allowing for improved measurement of infection status. Any person with HIV should be tested to clarify infection status and be educated to minimize future virus spread. The current CDC recommendations for HIV infection treatment are antiretroviral therapies, such as an HIV postexposure prophylaxis regimen, which consists of a cocktail of antiretrovirals and postexposure prophylaxis immediately for occupational exposures, such as accidental needlestick exposure from an HIV infected patient. To decrease accidental HIV stick injuries, there are safety precautions in place, that if followed, would help reduce this incidence. HIV accidental needle stick injuries still happen in the hospital workplace, but with proper education and treatment, if exposed, there is hope to minimize the effects.

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Section: Initial Hiv Infectionmentioning

confidence: 99%

Incidence and Risks of HIV Infection, Medication Options, and Adverse Effects in Accidental Needle Stick Injuries: A Narrative Review

Abadie,

Brown,

Campbell

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

HIV Diagnostics and Vaccines: It Takes Two to Tango

Colón,

Oriol-Mathieu,

Hural

et al. 2024

The Journal of Infectious Diseases

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Current serological tests for HIV screening and confirmation of infection present challenges to the adoption of HIV vaccines. The detection of vaccine-induced HIV-1 antibodies in the absence of HIV-1 infection, referred to as vaccine-induced seropositivity/seroreactivity, confounds the interpretation of test results, causing misclassification of HIV-1 status with potential affiliated stigmatization. For HIV vaccines to be widely adopted with high community confidence and uptake, tests that are agnostic to vaccination status (i.e., only positive for true HIV-1 infection) of tested individuals are needed. Successful development and deployment of such tests will require HIV vaccine developers to work in concert with diagnostic developers. Such tests will need to match today’s high-performance standards (accuracy, cost-effectiveness, simplicity) for use in both vaccinated and unvaccinated populations, especially in low- and middle-income countries with high HIV burden. Herein, we discuss the challenges and strategies for developing modified serological HIV tests for concurrent deployment with HIV vaccines.

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Towards Novel HIV-1 Serodiagnostic Tests without Vaccine-Induced Seroreactivity

Cited by 2 publications

References 33 publications

Incidence and Risks of HIV Infection, Medication Options, and Adverse Effects in Accidental Needle Stick Injuries: A Narrative Review

Incidence and Risks of HIV Infection, Medication Options, and Adverse Effects in Accidental Needle Stick Injuries: A Narrative Review

HIV Diagnostics and Vaccines: It Takes Two to Tango

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