Towards paired and coupled electrode reactions for clean organic microreactor electrosyntheses

Paddon, Christopher A.; Atobe, Mahito; Fuchigami, Toshio; He, Ping; Watts, Paul; Haswell, Stephen J.; Pritchard, Gareth J.; Bull, Steven D.; Marken, Frank

doi:10.1007/s10800-006-9122-2

Cited by 175 publications

(138 citation statements)

References 45 publications

(64 reference statements)

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“…Certainly, it is the overall chemical change in the cell that will determine the cell performance. A favorable strategy is a paired electrosynthesis where desirable transformations are carried out at both electrodes [6,7]. A more generally applicable approach, used in the methoxylation of N-formylpyrrolidine (see Scheme 1 above), is to use the counter electrode to maintain a constant pH along the channel although this will normally involve gas evolution and the resulting gas bubbles will have an influence on the performance of a cell with a channel of small dimensions.…”

Section: Introductionmentioning

confidence: 99%

Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis

Green¹,

Brown²,

Pletcher³

2015

J Flow Chem

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In order for microflow electrolysis cells to make their full contribution to routine laboratory organic synthesis, they must be capable of carrying out reactions with good selectivity and high conversion at a high rate of conversion. In addition to appropriate choice of the electrolysis medium and control of the overall cell chemistry, both the design of the electrolysis cell (including materials of construction) and the correct selection of the cell current and flow rate of the solution are critical in determining performance. The conclusions are tested using the methoxylation of N-formylpyrrolidine as the test reaction in a microflow electrolysis cell with a single, long, patterned flow channel.

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Section: Introductionmentioning

confidence: 99%

Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis

Green¹,

Brown²,

Pletcher³

2015

J Flow Chem

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“…A paired electrolysis [21] consisting of oxidation of ferrocene and the reduction of tetraethyl ethylenetetracarboxylate in ethanol was also achieved without intentionally added electrolyte using an electrochemical flow microreactor having a parallel plate-to-plate electrode configuration.…”

Section: Electrolysis Without Supporting Electrolytesmentioning

confidence: 99%

Electrochemical Reactions in Microreactors

Yoshida¹,

Nagaki²

2013

Microreactors in Preparative Chemistry

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“…A case in point is the paired electrosynthesis of cyanoacetic acid (used in several industrial processes and in dye-sensitized solar cells), through the cathodic reduction of CO 2 and the anodic oxidation of a tetraalkylammonium salt anion. 1 ■ ASSOCIATED CONTENT …”

Section: ■ Conclusionmentioning

confidence: 99%

A Demonstration of Simultaneous Electrochemiluminescence

et al. 2013

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Paired (simultaneous) electrochemical processes can increase energy savings in selected cases by using the reactions at both electrodes of an electrochemical cell to perform a desired process, as is the case in the commercially successful chlor-alkali process. In the demonstration described herein, simultaneous blue electrochemiluminescence (ECL) is obtained with luminol in a basic medium in a divided electrochemical cell. ECL is obtained in the anolyte through the direct oxidation of luminol, the reaction products of which interact with H 2 O 2 in the vicinity of the electrode to yield an excited emitting species. ECL is also obtained in the catholyte through an indirect, mediated process involving the initial reduction of ClO 2 − to ClO − , which then reacts with luminol and H 2 O 2 to produce the excited emitting species. The co-reactant (H 2 O 2 ) is needed to complete the reaction sequences in both compartments of the cell. This ECL phenomenon is visible to the naked eye in a darkened room at a distance of up to 5 m.

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Towards paired and coupled electrode reactions for clean organic microreactor electrosyntheses

Abstract: Electrosynthesis offers a powerful tool for the formation of anion and cation radical intermediates and for driving clean synthetic reactions without the need for additional chemical reagents.

Cited by 175 publications

References 45 publications

Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis

Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis

Electrochemical Reactions in Microreactors

A Demonstration of Simultaneous Electrochemiluminescence

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