Towards Personalized Intervention for Alzheimer’s Disease

Xing, Peng; Xing, Peiqi; Li, Xiuhui; Qian, Ying; Song, Fuhai; Bai, Zhouxian; Han, Guangchun; Lei, Hongxing

doi:10.1016/j.gpb.2016.01.006

Cited by 25 publications

(24 citation statements)

References 98 publications

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“…This system has made it possible to generate novel 3D neural cell culture models capable to recapitulate AD associated traits seen in post-mortem samples such as Aβ deposition similar to amyloid plaques, and NFT-like tau aggregates from patient iPSC-derived neurons or from genetically modified human stem cell lines; this pattern has not been feasible to be reproduced even in animal models [33]. These results reveal that iPSCs based technology together with 3D human cell culture models and genome editing are very promising tools to study human brain-like environment and open a new dimension for regenerative medicine, disease modeling and high-throughput drug screening to treat AD [34,35].…”

Section: Discussionmentioning

confidence: 99%

Out with the Old, in with the New… Strategies Based on Stem Cells to Design New Models of Alzheimer’s Disease

Revilla¹

2017

JSRT

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Since Yamanaka's group successfully discovered iPSCs technology a decade ago, new approaches for disease modeling have happened in the field. iPSCs have become the primary alternative to ESCs and is considered as a potential tool for modeling neurodegenerative diseases. The most prevalent form of dementia worldwide is AD, with aging being the major risk factor to develop it. Although it was described more than a hundred years ago, currently it doesn't exist a cure for this disorder, and ordinary treatments can only temporarily alleviate their symptoms. It has been reported that only 5% of AD cases are inherited, showing the remaining 95% a sporadic origin. Our understanding of AD pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the limitations to model the sporadic form of the disease. Given that, iPSCs can be derived from somatic cells of AD patients and subsequently be differentiated into neurons, the development of therapies based on the use of stem cells might be a promising novel tool for cellular replacement therapy, in addition to disease modeling and drug discovery for AD. Direct reprogramming, cocktails of small molecules, gene editing or 3D cell culture are among those new strategies that are improving the application of stem cells in regenerative medicine. Here, we show how present approaches in the field of iPSCs can contribute to create novel AD disease models.

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Section: Discussionmentioning

confidence: 99%

Out with the Old, in with the New… Strategies Based on Stem Cells to Design New Models of Alzheimer’s Disease

Revilla¹

2017

JSRT

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“…Therefore, it is common to try to treat AD in its early stages, with or without medication. Nonpharmacological strategies may be based on physical activity, brain stimulation, social communication, and diet-chemical substances (Peng et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Nonpharmacological treatment options for Alzheimer’s disease: from animal testing to clinical studies

Türkez¹,

Arslan²,

Stefano³

et al. 2020

Turk J Zool

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Despite extensive pharmacological approaches, there is no curative therapy for Alzheimer's disease (AD) or other types of dementias. While current pharmacological options alleviate some symptoms of AD, they can lead to various adverse effects. Hence, nonpharmacological treatment options for AD are often considered with the assumption that they are safe, effective, and economic in managing patients. Furthermore, studies on animal models have suggested that environmental exposures like diet, music, or rewardrelated actions can stimulate neuronal regeneration and differentiation without using any pharmacological factors. The aim of this review is to provide a summary of nonpharmacological treatment options for the management of cognitive, emotional, and behavioral symptoms of AD. In addition, this review provides an overview of the challenging and encouraging experiences and recent studies and problems in cognitive training related to animal models. Nonpharmacological studies of AD are discussed in this literature review in terms of animal models, physical activity, brain stimulation, and the role of social communication.

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“…Neuroprotective approaches in group C are the new extension of multiple effects from trophic factors secreted by genetically engineered cells or viral vector. Alternatively, stimulating the proliferation and differentiation of endogenous stem cells, application of induced pluripotent stem cells (iPSC), or mesenchymal stem cells are popular trends in scientific research to prevent neurodegeneration and neuronal loss [20][21][22].…”

Section: Introductionmentioning

confidence: 99%