Towards Personalized Treatment and Molecular Research on Gastrointestinal Tumors

Passardi, Alessandro; Scarpi, Emanuela; Ulivi, Paola

doi:10.3390/ijms241814283

IJMS

2023

DOI: 10.3390/ijms241814283

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Towards Personalized Treatment and Molecular Research on Gastrointestinal Tumors

Alessandro Passardi,

Emanuela Scarpi,

Paola Ulivi

Abstract: Gastrointestinal cancers (GC) account for 26% of all cancer incidences and 35% of all cancer-related deaths [...]

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2024

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Advances in the diagnosis and treatment of MET-variant digestive tract tumors

Zhang,

Dong,

Gao

et al. 2024

World J Gastrointest Oncol

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The receptor tyrosine kinase encoded by the MET gene plays an important role in various cellular processes such as growth, survival, migration and angiogenesis, and its abnormal activation is closely related to the occurrence and development of various tumors. This article reviews the recent advances in diagnosis and treatment of MET-variant digestive tract tumors. In terms of diagnosis, the application of next-generation sequencing technology and liquid biopsy technology makes the detection of MET variants more accurate and efficient, providing a reliable basis for individualized treatment. In terms of treatment, MET inhibitors such as crizotinib and cabotinib have shown good efficacy in clinical trials. In addition, the combination of immunotherapy and MET inhibitors also demonstrated potential synergies, further improving the therapeutic effect. However, the complexity and heterogeneity of drug resistance mechanisms are still one of the difficulties in current research. In the future, it is necessary to further deepen the understanding of the mechanism of MET variation and explore new combination treatment strategies to improve the overall survival rate and quality of life of patients. The diagnosis and treatment of MET-variant digestive tract tumors are moving towards precision and individualization, and have broad application prospects.

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Advances in the diagnosis and treatment of MET-variant digestive tract tumors

Zhang,

Dong,

Gao

et al. 2024

World J Gastrointest Oncol

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show abstract

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Towards Personalized Treatment and Molecular Research on Gastrointestinal Tumors

Abstract: Gastrointestinal cancers (GC) account for 26% of all cancer incidences and 35% of all cancer-related deaths [...]

Cited by 1 publication

References 5 publications

Advances in the diagnosis and treatment of MET-variant digestive tract tumors

Advances in the diagnosis and treatment of MET-variant digestive tract tumors

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