Towards potential antifungal agents: synthesis, supramolecular self-assembly and in vitro activity of azole mono-, sesqui- and diterpenoids

Abstract

Terpenes and their derivatives are natural antifungal and antimicrobial agents. In this paper, potential antifungal agents were developed on the basis of farnesol, geraniol, myrtenol, perillyl alcohol, cedrol and phytol....

Bio‐guided isolation of aromatic abietane diterpenoids from Salvia canariensis as biopesticides in the control of phytopathogenic fungi

“…The fact that its antifungal activity was not significant despite its lipophilicity could be attributed to its bulky five-ring structure that could hinder the penetration of the compound into the cell through the lipid layer due to steric hindrance. 28 This structure-activity relationship analysis (Fig. 9) is in accordance with previous works for other biological properties.…”

“…The fact that its antifungal activity was not significant despite its lipophilicity could be attributed to its bulky fivering structure that could hinder the penetration of the compound into the cell through the lipid layer due to steric hindrance. 28 It is worth noting that the antifungal activity of this triterpenoid against A. alternata and F. oxysporum has been previously reported. 42,43 In fact, Shu et al 43 described that ursolic acid inhibits A. alternata growth through a membrane-targeted mechanism and intracellular reactive oxygen species (ROS) accumulation.…”

“…This is because the lipophilic nature of the diterpenes can facilitate their transport across the cell membrane or affect the structure of the membrane, even destroying it. 28 ). The fact that its antifungal activity was not significant despite its lipophilicity could be attributed to its bulky five-ring structure that could hinder the penetration of the compound into the cell through the lipid layer due to steric hindrance.…”

Five Different Artemisia L. Species Ethanol Extracts’ Phytochemical Composition and Their Antimicrobial and Nematocide Activity

“…In the experiments, the determination of the minimum inhibitory concentration (MIC) of the extracts of the following cultivar plants, A. annua , A. dracunculus , A. santonica , A. abrotanum , and A. scoparia , was performed using the method of two-fold serial dilution [ 116 ] with the modification provided in [ 117 , 118 ]. Fungistatic activity was defined by the serial dilution method [ 119 ] in liquid medium.…”

Syntheses and polymerization of monoterpene-based (meth)acrylates: IBO(M)A as a relevant monomer for industrial applications

“…For the integration of that chemical motif, Akhmedov et al converted several terpenes, such as geraniol ( 15 ) and myrtenol ( 11 ), with stochiometric amounts of acryloyl chloride and Hünig-base in chloroform to the corresponding acrylates in small-scale reactions. 41 The reaction time was 10 h at room temperature, and purification by column chromatography was required. The yield of myrtenyl acrylate ( A11 ) was 72%.…”