Towards precision pain medicine for pain after cancer: the Cancer Pain Phenotyping Network multidisciplinary international guidelines for pain phenotyping using nociplastic pain criteria

Phenotyping of chronic pain in breast cancer survivors: an original study using the cancer pain phenotyping (CANPPHE) Network multidisciplinary international guidelines

“…This research is among the pioneering studies to characterize pain in BCS according to the current terminology applied by the IASP and the latest guideline on post-cancer pain phenotyping from the international and multidisciplinary CANPPHE Network [ 19 ]. Our study may help to promote classification according to pain phenotype in the pain management of BCS and contribute to the implementation of precision medicine, an approach being widely adopted in the management of many diseases [ 49 ].…”

“…The stepwise classification procedure used in this study to identify nociceptive, neuropathic, and nociplastic pain was based on the IASP guideline developed by Kosek et al in 2021 [ 11 ] and applied to post-cancer pain in 2023 by the international, multidisciplinary CANPPHE network [ 19 ]. The method consists of seven steps in total (Supplement 2 ).…”

“…Therefore, the ‘nociplastic pain’ term was introduced by the IASP in 2017. Furthermore, an updated stepwise classification system for post-cancer pain has since been proposed by the multidisciplinary international Cancer Pain Phenotyping (CANPPHE) Network in 2023 [ 19 ]. The advances in the field of cancer pain phenotyping create an important research question: do the previous findings regarding the prevalence of the 3 pain phenotypes in BCS, as previously documented [ 14 ], still stand with the CANPPHE pain phenotyping guidelines [ 19 ].…”

“…Furthermore, an updated stepwise classification system for post-cancer pain has since been proposed by the multidisciplinary international Cancer Pain Phenotyping (CANPPHE) Network in 2023 [ 19 ]. The advances in the field of cancer pain phenotyping create an important research question: do the previous findings regarding the prevalence of the 3 pain phenotypes in BCS, as previously documented [ 14 ], still stand with the CANPPHE pain phenotyping guidelines [ 19 ]. Therefore, the primary aim of this cross-sectional study is to examine the prevalence of pain phenotypes in BCS considering the recent advances in pain phenotyping.…”

Effects of Physical Exercise and Motor Activity on Oxidative Stress and Inflammation in Post-Mastectomy Pain Syndrome

“…Central sensitizitation is defined as an amplification of neural signalling within the central nervous system that elicits pain hypersensitivity [ 6 ]. The need for early recognition of central sensitization in patients with chronic pain was raised by the International Association for the Study of Pain (IASP), who recently introduced the term “nociplastic pain” as a third mechanistic pain descriptor in addition to nociceptive (pain attributable to the activation of the peripheral receptive terminals of primary afferent neurones in response to noxious chemical, mechanical, or thermal stimuli) and neuropathic (pain caused by a primary lesion or disease of the somatosensory nervous system) pain [ 7 ]. Nociplastic pain is defined by the IASP as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain” [ 8 ].…”