Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography

Zhang, Tao; Zhou, Junli; Carney, Paul R.; Jiang, Huabei

doi:10.1016/j.jneumeth.2014.10.018

Cited by 16 publications

(12 citation statements)

References 42 publications

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“…As one of the major technical advances in the past few years, 3D printing technique has been widely applied to the medical field such as dentistry, surgery and prosthetic development , due to its low cost, high speed, precision and accuracy. 3D printing has also been utilized to fabricate interfaces for optical brain imaging in animal studies . Benefited from the 3D printing technique and the mature wearable EEG cap technique, in our study, a 3‐layer DOT head interface was implemented: the outer layer was 3D printed with PLA material for initial orientation and weight support, the inner layer was printed with flexible rubber material for tight/comfort connection between the fiber bundles and head surface, and the modified 256‐channel EEG cap was used for final orientation and housing of the source/detector fibers.…”

Section: Resultsmentioning

confidence: 99%

“…The DOT data acquisition system used was described in detail elsewhere in our previous animal studies . Briefly, 144 light‐emitting diodes (LEDs) were used as the excitation sources, while highly sensitive avalanche photodiodes were utilized as light detectors.…”

Section: Methodsmentioning

confidence: 99%

“…By analyzing scattering coefficient spectra, we detected the emergence of approximately a 0.3‐Hz frequency in hippocampal signal spectra of PTZ‐induced rats exhibiting generalized seizure activity that was undetectable in control rats . We demonstrated a miniature‐probe‐based implantable integrated DOT and ESL system capable of chronically recording seizures and localizing the seizure onset zone , and developed a subject‐specific helmet suitable for real‐time detection of seizures in awake rats , because hemodynamic responses elicited by seizure‐induced drugs may differ between anesthetized and un‐anesthetized animals.…”

Section: Introductionmentioning

confidence: 99%

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Fast noninvasive functional diffuse optical tomography for brain imaging

Dai

Zhang

Yang

et al. 2017

Journal of Biophotonics

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Advances in epilepsy studies have shown that specific changes in hemodynamics precede and accompany seizure onset and propagation. However, it has been challenging to noninvasively detect these changes in real time and in humans, due to the lack of fast functional neuroimaging tools. In this study, we present a functional diffuse optical tomography (DOT) method with the guidance of an anatomical human head atlas for 3-dimensionally mapping the brain in real time. Central to our DOT system is a human head interface coupled with a technique that can incorporate topological information of the brain surface into the DOT image reconstruction. The performance of the DOT system was tested by imaging motor tasks-involved brain activities on N = 6 subjects (3 epilepsy patients and 3 healthy controls). We observed diffuse areas of activations from the reconstructed [HbT] images of patients, relative to more focal activations for healthy subjects. Moreover, significant pretask hemodynamic activations were also seen in the motor cortex of patients, which indicated abnormal activities persistent in the brain of an epilepsy patient. This work demonstrates that fast functional DOT is a valuable tool for noninvasive 3-dimensional mapping of brain hemodynamics.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fast noninvasive functional diffuse optical tomography for brain imaging

Dai

Zhang

Yang

et al. 2017

Journal of Biophotonics

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“…The image reconstruction time was limited by CPU-based computer system. Graphic processing units (GPU) based parallel reconstruction algorithm can be developed to accelerate the image reconstruction, which was proved to be a powerful tool in our previous work [31]. In addition, the time desired for data acquisition needs to be significantly reduced to perform real-time image-guided surgery.…”

Section: Animal Experimentsmentioning

confidence: 99%

FMTPen: A Miniaturized Handheld Fluorescence Molecular Tomography Probe for Image-Guided Cancer Surgery

Yang

Dai

et al. 2015

Photonics

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Abstract:We described a novel handheld device (termed FMTPen) for three-dimensional (3D) fluorescence molecular tomography (FMT). The FMTpen is characterized by its bendable structure and miniaturized size (10 mm in diameter) that can be potentially used as an intraoperative tool for the detection of tumor margins and for image-guided surgery. Several phantom experiments based on indocyanine green (ICG), an FDA approved near-infrared (NIR) fluorescent dye, were conducted to evaluate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (NIR-830-ATF68-IONP and NIR-830-ZHER2:343-IONP, respectively) and were then imaged to further demonstrate the ability of this FMT probe for imaging small animals.

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“…Localization and real-time monitoring of spontaneous and evoked neuronal activity in the brain are important in understanding the functional characteristics of neural networks and brain function (Bouchard et al, 2009; Inyushin et al, 2013; Lenkov et al, 2012; Silasi et al, 2016; Zhang et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue

Tsytsarev

Akkentli

Pumbo

et al. 2017

Journal of Neuroscience Methods

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Background Brain imaging methods are continually improving. Imaging of the cerebral cortex is widely used in both animal experiments and charting human brain function in health and disease. Among the animal models, the rodent cerebral cortex has been widely used because of patterned neural representation of the whiskers on the snout and relative ease of activating cortical tissue with whisker stimulation. New Method We tested a new planar solid-state oxygen sensor comprising a polymeric film with a phosphorescent oxygen-sensitive coating on the working side, to monitor dynamics of oxygen metabolism in the cerebral cortex following sensory stimulation. Results Sensory stimulation led to changes in oxygenation and deoxygenation processes of activated areas in the barrel cortex. We demonstrate the possibility of dynamic mapping of relative changes in oxygenation in live mouse brain tissue with such a sensor. Comparison with Existing Method Oxygenation-based functional magnetic resonance imaging (fMRI) is very effective method for functional brain mapping but have high costs and limited spatial resolution. Optical imaging of intrinsic signal (IOS) does not provide the required sensitivity, and voltage-sensitive dye optical imaging (VSDi) has limited applicability due to significant toxicity of the voltage-sensitive dye. Our planar solid-state oxygen sensor imaging approach circumvents these limitations, providing a simple optical contrast agent with low toxicity and rapid application. Conclusions The planar solid-state oxygen sensor described here can be used as a tool in visualization and real-time analysis of sensory-evoked neural activity in vivo. Further, this approach allows visualization of local neural activity with high temporal and spatial resolution.

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Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography

Abstract: 2016-12-23T18:47:23

Cited by 16 publications

References 42 publications

Fast noninvasive functional diffuse optical tomography for brain imaging

Fast noninvasive functional diffuse optical tomography for brain imaging

FMTPen: A Miniaturized Handheld Fluorescence Molecular Tomography Probe for Image-Guided Cancer Surgery

Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue

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