Towards regulation of Endocrine Disrupting chemicals (EDCs) in water resources using bioassays – A guide to developing a testing strategy

Robitaille, Julie; Denslow, Nancy D.; Escher, Beate I.; Kurita-Oyamada, Hajime; Marlatt, Vicki L.; Martyniuk, Christopher J.; Navarro‐Martín, Laia; Prosser, Ryan S.; Sanderson, J. Thomas; Yargeau, Viviane; Langlois, Valérie S.

doi:10.1016/j.envres.2021.112483

Cited by 42 publications

(17 citation statements)

References 259 publications

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“…Hence, in vitro bioassays enabled the detection of chemical hazards that would have been missed using chemical analysis alone. The limit of quantification for chemical analysis (0.04–1.5 ng/L for 17β-estradiol in surface water and 0.05–3 ng/L for 17β-estradiol in wastewater effluent) is higher than that for in vitro bioassays such as ERα CALUX (as low as 0.002 ng/L), with robust EBTs available for estrogenic activity …”

Section: Case Studiesmentioning

confidence: 98%

“…The limit of quantification for chemical analysis (0.04−1.5 ng/L for 17β-estradiol in surface water and 0.05−3 ng/L for 17β-estradiol in wastewater effluent) is higher than that for in vitro bioassays such as ERα CALUX (as low as 0.002 ng/L), 71 with robust EBTs available for estrogenic activity. 72 In another example, Magdeburg et al 73 assessed changes in chemical concentrations and biological effect in a pilot advanced wastewater treatment plant with conventional biological activated sludge, ozonation, and sand filtration. Ozonation reduced the concentration of most analyzed chemicals by >90%.…”

Section: Are There Examples That Demonstrate How the Application Of E...mentioning

confidence: 99%

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Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers

Neale

Escher

Baat

et al. 2023

Environ. Sci. Technol.

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Effect-based methods (EBM) have great potential for water quality monitoring as they can detect the mixture effects of all active known and unknown chemicals in a sample, which cannot be addressed by chemical analysis alone. To date, EBM have primarily been applied in a research context, with a lower level of uptake by the water sector and regulators. This is partly due to concerns regarding the reliability and interpretation of EBM. Using evidence from the peer-reviewed literature, this work aims to answer frequently asked questions about EBM. The questions were identified through consultation with the water industry and regulators and cover topics related to the basis for using EBM, practical considerations regarding reliability, sampling for EBM and quality control, and what to do with the information provided by EBM. The information provided in this work aims to give confidence to regulators and the water sector to stimulate the application of EBM for water quality monitoring.

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Section: Case Studiesmentioning

confidence: 98%

Section: Are There Examples That Demonstrate How the Application Of E...mentioning

confidence: 99%

Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers

Neale

Escher

Baat

et al. 2023

Environ. Sci. Technol.

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“…Bioassays can be run with raw MWRC (demonstrating a worst-case scenario) or diluted MWRC to evaluate ecotoxicity scenarios. Furthermore, effect-directed analysis could be run to probe the relationship between biological responses and the chemical composition of MWRC (or fractionated MWRC) . As a result, these analyses may be critical for identifying needs for industrial pretreatment of wastewater or post-treatment of MWRC to protect natural ecosystems.…”

Section: Enabling Reuse Through Mwrc Regulationsmentioning

confidence: 99%

The Future of Municipal Wastewater Reuse Concentrate Management: Drivers, Challenges, and Opportunities

Finnerty,

Childress,

Hardy

et al. 2023

Environ. Sci. Technol.

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Water reuse is rapidly becoming an integral feature of resilient water systems, where municipal wastewater undergoes advanced treatment, typically involving a sequence of ultrafiltration (UF), reverse osmosis (RO), and an advanced oxidation process (AOP). When RO is used, a concentrated waste stream is produced that is elevated in not only total dissolved solids but also metals, nutrients, and micropollutants that have passed through conventional wastewater treatment. Management of this RO concentrate�dubbed municipal wastewater reuse concentrate (MWRC)�will be critical to address, especially as water reuse practices become more widespread. Building on existing brine management practices, this review explores MWRC management options by identifying infrastructural needs and opportunities for multi-beneficial disposal. To safeguard environmental systems from the potential hazards of MWRC, disposal, monitoring, and regulatory techniques are discussed to promote the safety and affordability of implementing MWRC management. Furthermore, opportunities for resource recovery and valorization are differentiated, while economic techniques to revamp cost-benefit analysis for MWRC management are examined. The goal of this critical review is to create a common foundation for researchers, practitioners, and regulators by providing an interdisciplinary set of tools and frameworks to address the impending challenges and emerging opportunities of MWRC management.

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“…Vitellogenin (VTG) is generally produced in the liver of female vertebrate ovaries in response to circulating endogenous estrogen [48,49] and is a precursor to the turbulence protein. Once produced in the liver, it follows the blood flow to the ovary, where it is absorbed.…”

Section: Evaluation Of Functions Using Spheroid-based In Vitro Assaysmentioning

confidence: 99%

Integration of Bioinspired Fibrous Strands with 3D Spheroids for Environmental Hazard Monitoring

Park

Jun

Lee

et al. 2022

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Numerous methods have been introduced to produce 3D cell cultures that can reduce the need for animal experimentation. This study presents a unique 3D culture platform that features bioinspired strands of electrospun nanofibers (BSeNs) and aquatic cell lines to compensate for shortcomings in the current cell spheroid generation techniques. The use of BSeNs in 3D zebrafish liver cell cultures is found to improve liver and reproductive functions through spheroid‐based in vitro assays such as whole transcriptome sequencing and reproductive toxicity testing, with optimized properties exhibiting results similar to those obtained for fish embryo acute toxicity (FET, OECD TG 236) following exposure to environmental endocrine‐disrupting chemicals (17β‐Estradiol (E2), 4‐hydroxytamoxifen (4‐HT), and bisphenol compounds (bisphenol A (BPA) and 9,9‐Bis(4‐hydroxyphenyl)fluorene (BPFL)). These findings indicate that the beneficial effects of bioinspired materials that closely mimic ECM environments can yield efficient zebrafish cells with intrinsic functions and xenobiotic metabolism similar to those of zebrafish embryos. As a closer analog for the in vivo conditions that are associated with exposure to potentially hazardous chemicals, the straightforward culture model introduced in this study shows promise as an alternative tool that can be used to further eco‐environmental assessment.

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Towards regulation of Endocrine Disrupting chemicals (EDCs) in water resources using bioassays – A guide to developing a testing strategy

Cited by 42 publications

References 259 publications

Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers

Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers

The Future of Municipal Wastewater Reuse Concentrate Management: Drivers, Challenges, and Opportunities

Integration of Bioinspired Fibrous Strands with 3D Spheroids for Environmental Hazard Monitoring

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