Towards reliability enhancement of graphene FET biosensor in complex analyte: Artificial neural network approach

Basu, J.; Samanta, N.; Jana, Sukhendu; RoyChaudhuri, C.

doi:10.1016/j.microrel.2018.09.001

Cited by 16 publications

(14 citation statements)

References 28 publications

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“…Accurate biosensor design requires fundamental knowledge on the chemical structure of the target NPs, the concentration levels of the analyte [ 36 ] and its interfering species, the type of matrix, and the type and volume of the sample [ 37 ]. The next step is selecting a biological process that mediates the detection of the target analyte [ 38 ].…”

Section: Biosensors Design For Detection Of Npsmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

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Natural products (NPs) are a valuable source in the food, pharmaceutical, agricultural, environmental, and many other industrial sectors. Their beneficial properties along with their potential toxicities make the detection, determination or quantification of NPs essential for their application. The advanced instrumental methods require time-consuming sample preparation and analysis. In contrast, biosensors allow rapid detection of NPs, especially in complex media, and are the preferred choice of detection when speed and high throughput are intended. Here, we review diverse biosensors reported for the detection of NPs. The emerging approaches for improving the efficiency of biosensors, such as microfluidics, nanotechnology, and magnetic beads, are also discussed. The simultaneous use of two detection techniques is suggested as a robust strategy for precise detection of a specific NP with structural complexity in complicated matrices. The parallel detection of a variety of NPs structures or biological activities in a mixture of extract in a single detection phase is among the anticipated future advancements in this field which can be achieved using multisystem biosensors applying multiple flow cells, sensing elements, and detection mechanisms on miniaturized folded chips.

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Section: Biosensors Design For Detection Of Npsmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

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“…Then a sinusoidal voltage for 60 s has been applied (peak to peak 19.5 V). To improve the adhesion, the graphene deposited SPEs have been heated for 20 min at 75 °C 37 . After that, ZnO seed layer has been grown on graphene deposited SPEs incorporating sol–gel method.…”

Section: Methodsmentioning

confidence: 99%

Label free, electric field mediated ultrasensitive electrochemical point-of-care device for CEA detection

Chakraborty

Das

Mandal

et al. 2021

Sci Rep

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Developing point-of-care (PoC) diagnostic platforms for carcinoembryonic antigen detection is essential. However, thefew implementations of transferring the signal amplification strategies in electrochemical sensing on paper-based platforms are not satisfactory in terms of detection limit (LOD). In the quest for pushing down LOD, majority of the research has been targeted towards development of improved nanostructured substrates for entrapping more analyte molecules and augmenting the electron transfer rate to the working electrode. But, such approaches have reached saturation. This paper focuses on enhancing the mass transport of the analyte towards the sensor surface through the application of an electric field, in graphene-ZnO nanorods heterostructure. These hybrid nanostructures have been deposited on flexible polyethylene terephthalate substrates with screen printed electrodes for PoC application. The ZnO nanorods have been functionalized with aptamers and the working sensor has been integrated with smartphone interfaced indigenously developed low cost potentiostat. The performance of the system, requiring only 50 µl analyte has been evaluated using electrochemical impedance spectroscopy and validated against commercially available ELISA kit. Limit of detection of 1 fg/ml in human serum with 6.5% coefficient of variation has been demonstrated, which is more than three orders of magnitude lower than the existing attempts on PoC device.

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“…Notably, this repeatability analysis is often limited by the scalability of the measurements and the subjectivity of the experimenters . To this end, some groups employed 50–250 technical replicates based on large arrays of 2D FET sensors, which enables statistically robust analysis of the performance. ,, …”

Section: Prototypical Designmentioning

confidence: 99%

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

2022

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The evolutionary success in information technology has been sustained by the rapid growth of sensor technology. Recently, advances in sensor technology have promoted the ambitious requirement to build intelligent systems that can be controlled by external stimuli along with independent operation, adaptivity, and low energy expenditure. Among various sensing techniques, field-effect transistors (FETs) with channels made of two-dimensional (2D) materials attract increasing attention for advantages such as label-free detection, fast response, easy operation, and capability of integration. With atomic thickness, 2D materials restrict the carrier flow within the material surface and expose it directly to the external environment, leading to efficient signal acquisition and conversion. This review summarizes the latest advances of 2D-materials-based FET (2D FET) sensors in a comprehensive manner that contains the material, operating principles, fabrication technologies, proof-of-concept applications, and prototypes. First, a brief description of the background and fundamentals is provided. The subsequent contents summarize physical, chemical, and biological 2D FET sensors and their applications. Then, we highlight the challenges of their commercialization and discuss corresponding solution techniques. The following section presents a systematic survey of recent progress in developing commercial prototypes. Lastly, we summarize the long-standing efforts and prospective future development of 2D FET-based sensing systems toward commercialization.

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Towards reliability enhancement of graphene FET biosensor in complex analyte: Artificial neural network approach

Cited by 16 publications

References 28 publications

Emerging biosensors in detection of natural products

Emerging biosensors in detection of natural products

Label free, electric field mediated ultrasensitive electrochemical point-of-care device for CEA detection

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

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