Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females

Abstract

Objectives The aim of this study was to identify sex-specific prevalence and strength of risk factors for the incidence of radiographic knee osteoarthritis (incRKOA). Methods Our study population consisted of 10,958 Rotterdam Study participants free of knee OA in one/both knees at baseline. 1064 participants developed RKOA after a median follow-up time of 9.6 years. We estimated the association between each available risk factor and incRKOA using sex stratified multivariate regression models with generalized estimating equations. Subsequently, we statistically tested sex differences between risk estimates and calculated the population attributable fractions (PAFs) for modifiable risk factors. Results The prevalence of the investigated risk factors was, in general, higher in women compared to men, except alcohol intake and smoking was higher in men and high BMI showed equal prevalence. We found significantly different risk estimates between men and women: high level of PA (RR 1.76, 95% CI 1.29-2.40) or a KL-score 1 at baseline (RR 5.48, 95% CI 4.51-6.65) was higher in men. Among borderline significantly different risk estimates was BMI ≥27, associated with higher risk for incRKOA in women (RR 2.00, 95% CI 1.74-2.31). The PAF for higher BMI was 25.6% in women and 19.3% in men. Conclusion We found sex-specific differences in both presence and relative risks of several risk factors for incRKOA. Especially BMI, a modifiable risk factor, impacts women more strongly than men. These risk factors can be used in the development of personalized prevention strategies and in building sex-specific prediction tools to identify high-risk profile patients.

Clinical Profile Of Knee Osteoarthritis In The Medical Rehabilitation Outpatient Installation Of Dr. Soetomo General Hospital Surabaya

“…From a study that was conducted by Szilagyi, I., et al (2021) they discovered that when compared to men, the prevalence of risk factors was generally higher in women, but not in alcohol consumption and smoking. They found significant results in their study, the PAF (population attributable fractions) for BMI in women was 25.6% and 19.3% in men [15]. Another study that was conducted by Vina, E. R., et al, (2018), they found that there are race and genetic factors in an addition to gender factors that affect the worsening of knee OA.…”

Knee and Peri-Knee Tissues of Post Mortem Donors Are Strategic Sources of Mesenchymal Stem/Stromal Cells for Regenerative Procedures

“…In addition to comparisons of these three tissues in terms of their potential for isolating MSC-like cells in vitro, we also compared the three groups of donors according to the times post mortem within each tissue, before the tissues were harvested: ≤24 h; 24 to 48 h; ≥48 h. There were no differences between the time post mortem groups for age, sex ratio, and body mass index, which are well-recognized risk factors for osteoarthritis [ 28 ]. Here, these three tissues were available for harvesting in greater quantities than for living donors, with the weight of the harvested biopsies highest for the tibial subchondral BM and synovium, compared to periosteum.…”

Association between hip pain and radiographic hip osteoarthritis in primary care: the CHECK cohort

“…We then performed post-hoc sensitivity analyses. First, since the difference between sexes remained unclear in prior research, we performed sex-stratified analyses and used the Z-test statistic (28,29) to test for differences in associations between men and women. Second, we repeated the analyses between self-reported hip pain and ROA in a more strictly defined control group, containing only participants without any self-reported hip pain, and thus excluding pain-free hips with a contralateral painful hip.…”