Failure of power system components cause undue interruptions to Power Supply thereby affecting the Overall System reliability. Consequently, Power system reliability assessment is important for high-quality and continuous power delivery to consumers. This chapter presents the reliability assessment of Mofor Injection Substation. The performance evaluation of Mofor Injection Substation is evaluated using various system parameters which regulate the operation of the Substation. Statistical data from January, 2017 to December, 2017 were used to analyze the Substation. The results gave a power availability index (ASAI) of 0.7683796 and 0.768968 for Ekete and Orhuworun substation, respectively, due to the unavailability of strategically placed distributed generators (DGs). The aforementioned reliability result revealed that the power distribution at Mofor Injection Substation can be said to be unreliable, inefficient, undesirable, and Unstable.