Towards the 2D velocity reconstruction in abdominal aorta from Color-Doppler Ultrasound

Antonuccio, Maria Nicole; Morales, Hernán G.; This, Alexandre; Capellini, Katia; Avril, Stéphane; Celi, Simona; Rouet, Laurence

doi:10.1016/j.medengphy.2022.103873

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…Additionally, the AAA models can be used for applications that aim at personalized investigation, such as clinical imaging, surgical training, intervention planning, or therapeutic management that are strictly patient-specific. For instance, a hemodynamic characterization can be performed by processing Color-Doppler images ( 57 ) acquired on these models with the noticeable advantage of investigating multiple flow conditions at the inlet, flow splitting at the outlets, and different geometries. However, prospective studies with effective outcomes are beneficial to prove the actual clinical utility of patient-specific AAA models.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of deformable patient-specific AAA models by material casting techniques

Antonuccio,

Gasparotti,

Bardi

et al. 2023

Front. Cardiovasc. Med.

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BackgroundAbdominal Aortic Aneurysm (AAA) is a balloon-like dilatation that can be life-threatening if not treated. Fabricating patient-specific AAA models can be beneficial for in-vitro investigations of hemodynamics, as well as for pre-surgical planning and training, testing the effectiveness of different interventions, or developing new surgical procedures. The current direct additive manufacturing techniques cannot simultaneously ensure the flexibility and transparency of models required by some applications. Therefore, casting techniques are presented to overcome these limitations and make the manufactured models suitable for in-vitro hemodynamic investigations, such as particle image velocimetry (PIV) measurements or medical imaging.MethodsTwo complex patient-specific AAA geometries were considered, and the related 3D models were fabricated through material casting. In particular, two casting approaches, i.e. lost molds and lost core casting, were investigated and tested to manufacture the deformable AAA models. The manufactured models were acquired by magnetic resonance, computed tomography (CT), ultrasound imaging, and PIV. In particular, CT scans were segmented to generate a volumetric reconstruction for each manufactured model that was compared to a reference model to assess the accuracy of the manufacturing process.ResultsBoth lost molds and lost core casting techniques were successful in the manufacturing of the models. The lost molds casting allowed a high-level surface finish in the final 3D model. In this first case, the average signed distance between the manufactured model and the reference was (−0.2±0.2) mm. However, this approach was more expensive and time-consuming. On the other hand, the lost core casting was more affordable and allowed the reuse of the external molds to fabricate multiple copies of the same AAA model. In this second case, the average signed distance between the manufactured model and the reference was (0.1±0.6) mm. However, the final model’s surface finish quality was poorer compared to the model obtained by lost molds casting as the sealing of the outer molds was not as firm as the other casting technique.ConclusionsBoth lost molds and lost core casting techniques can be used for manufacturing patient-specific deformable AAA models suitable for hemodynamic investigations, including medical imaging and PIV.

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Section: Discussionmentioning

confidence: 99%

Fabrication of deformable patient-specific AAA models by material casting techniques

Antonuccio,

Gasparotti,

Bardi

et al. 2023

Front. Cardiovasc. Med.

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Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair

Wang,

Zhang,

Mao

et al. 2024

Advanced Science

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Abdominal aortic aneurysms (AAAs) involve localized dilation of the abdominal aorta, with the reversal of this condition being significantly limited by the inherently poor and abnormal regenerative repair of the aortic elastic matrix. Mesenchymal stem cell exosomes (MSCEs) are promising regenerative tools; however, achieving precise targeting of AAA with MSCEs is challenging owing to the high blood flow in the arterial system. In this study, an engineered exosomal nanomotor is developed for magnetic and chemical propulsion. The results demonstrate that this nanomotor effectively enhances the delivery of MSCEs to the AAA through magnetic field navigation and catalase‐induced chemotaxis. The nanomotor significantly enhances the elastic matrix repair, reduces oxidative stress, and activates the PI3K/Akt pathway, leading to aneurysm shrinkage and reversal. In addition, the nanomotor possesses magnetic resonance imaging capabilities. The use of this nanomotor offers a novel, targeted drug delivery system in a rat model of AAA and holds promise as a potential therapeutic option for this condition.

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A Hybrid Mock Circulatory Loop for Fluid Dynamic Characterization of 3D Anatomical Phantoms

Bardi

Gasparotti

Vignali

et al. 2023

IEEE Trans. Biomed. Eng.

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Towards the 2D velocity reconstruction in abdominal aorta from Color-Doppler Ultrasound

Cited by 6 publications

References 30 publications

Fabrication of deformable patient-specific AAA models by material casting techniques

Fabrication of deformable patient-specific AAA models by material casting techniques

Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair

A Hybrid Mock Circulatory Loop for Fluid Dynamic Characterization of 3D Anatomical Phantoms

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