Towards the advance of a novel iontophoretic patch for needle-free buccal anesthesia

Couto, Renê Oliveira do; Cubayachi, Camila; Duarte, Maíra Peres Ferreira; Lopez, Renata Fonseca Vianna; Pedrazzi, Vinícius; Gaitani, Cristiane Masetto de; Freitas, Osvaldo de

doi:10.1016/j.msec.2020.111778

Cited by 12 publications

(18 citation statements)

References 40 publications

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Section: Smart Intraoral Drug Delivery Systemsmentioning

confidence: 99%

“…101 Encouragingly, they have proven to exhibit a longer retention time at the delivery site than adherent semi-solid systems. 102 Mucoadhesive monolayer patches, 103 multifunctional mucoadhesive bilayer patches, 82 and innovative iontophoresis patches 104 have extensively been developed for intraoral mucosal drug delivery. Recently, Abruzzo et al 105 prepared a mucoadhesive intraoral film for local delivery of Lactobacillus brevis CD2.…”

Section: Intraoral Mucoadhesive Systemsmentioning

confidence: 99%

“…A novel iontophoretic patch for needle-free intraoral anesthesia was invented as research continued. 104 The system consisted of three distinct layers, including a drug release layer, a mucoadhesive layer, and a backing layer. To enable iontophoresis, an anode electrode was inserted between the drug release and mucoadhesive/backing layers, which significantly enhanced the influx of prilocaine and lidocaine (Figure 8A,B).…”

Section: Physically Assisted Systemsmentioning

confidence: 99%

“…By way of illustration, Cubayachi et al 139 took advantage of iontophoresis to promote the penetration of hydrogel carrying local anesthetics into the intraoral mucosa of pigs. A novel iontophoretic patch for needle‐free intraoral anesthesia was invented as research continued 104 . The system consisted of three distinct layers, including a drug release layer, a mucoadhesive layer, and a backing layer.…”

Section: Smart Intraoral Drug Delivery Systemsmentioning

confidence: 99%

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Smart intraoral systems for advanced drug delivery

Liu

Guo

et al. 2022

MedComm – Biomaterials and Applications

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Drug administration through the oral cavity is considered to be a convenient, effective, and time-saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties.Without the degradation in gastrointestinal tract and first-pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproduc-MedComm -Biomaterials and Applications.

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Section: Smart Intraoral Drug Delivery Systemsmentioning

confidence: 99%

Section: Intraoral Mucoadhesive Systemsmentioning

confidence: 99%

Section: Physically Assisted Systemsmentioning

confidence: 99%

Section: Smart Intraoral Drug Delivery Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Smart intraoral systems for advanced drug delivery

Liu

Guo

et al. 2022

MedComm – Biomaterials and Applications

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“…[10][11][12][13][14] In pursuit of this, the suitability of a broad range of pharmaceutical technologies has been investigated and extensively revised in other papers. 15,16,17 Within this context, over the last decade, our multidisciplinary research group has also been driving towards advances in several needle-free and patient/dentist-friendly anesthetic delivery systems, such as buffered solutions, 18 mucoadhesive gels, 19 oral-dispersible tablets, 20 thin polymeric films 21,22 and multilayered iontophoretic patches 23 containing prilocaine and lidocaine hydrochlorides (PCl and LCl, respectively).…”

Section: Introductionmentioning

confidence: 99%

Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures

et al. 2021

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Intraoral medical devices for sustained drug delivery

Alghanem,

Dziurkowska,

Ordyniec-Kwaśnica

et al. 2023

Clin Oral Invest

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Objectives The oral cavity constitutes an attractive organ for the local and systemic application of drug substances. Oromucosal tablets, gels, or sprays are examples of the formulations applied. Due to the elution through the saliva, the residence time of the formulation at the application site is relatively short. Medical devices placed in the oral cavity, with a reservoir for an active substance, play an important role in solving this problem. Materials and methods In this review, we discuss the devices described in the literature that are designed to be used in the oral cavity, highlighting the advantages, disadvantages, and clinical applications of each of them. Results Among the intraoral medical devices, special types are personalized 3D-printed devices, iontophoretic devices, and microneedle patches. Conclusion We anticipate that with the development of 3D printing and new polymers, the technology of flexible and comfortable devices for prolonged drug delivery in the oral cavity will develop intensively. Clinical relevance The presented review is therefore a useful summary of the current technological state, when in fact none of the existing devices has been widely accepted clinically.

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Towards the advance of a novel iontophoretic patch for needle-free buccal anesthesia

Cited by 12 publications

References 40 publications

Smart intraoral systems for advanced drug delivery

Smart intraoral systems for advanced drug delivery

Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures

Intraoral medical devices for sustained drug delivery

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