Towards the antioxidant therapy in Osteoarthritis: Contribution of nanotechnology

González-Rodrı́guez, Marı́a Luisa; Fernández-Romero, Ana-María; Rabasco, A. M.

doi:10.1016/j.jddst.2017.04.032

Cited by 16 publications

(14 citation statements)

References 109 publications

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“…All these characteristics condition the administration of antioxidants in high doses for satisfactory efficiency. Some authors noted that the treatment for KOA is recommended to be delivered directly into the synovial capsule, the location of the affected tissues being an advantage in this regard [ 179 , 180 ], although this practice sometimes showed a weak penetration of the cartilage [ 181 ]. Lately, nanotechnology has offered solutions to overcome some of the shortcomings discussed above.…”

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

“…Consequently, it is complicated, or almost impossible, to establish a metabolic pathway from ingestion of exogenous antioxidants to the site of action represented by the knee. Given the existence of many publications in the field, we selected some antioxidants with beneficial effects in relieving OA, in order to analyze how they are metabolized in the human body and which are the key factors conditioning the pathology improvement [ 179 ].…”

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

“…Although oral curcumin supplementation has shown therapeutic efficacy in many clinical studies, its properties are counteracted by reduced bioavailability, low absorption, rapid metabolism, and elimination [ 213 ]. These shortcomings can be avoided using various drug formulations [ 179 , 213 ]. The curcumin metabolism occurs through oxidation, cleavage, conjugation, and reduction.…”

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

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The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

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Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.

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Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

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The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

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“…Non-steroidal anti-inflammatory drugs (NSAIDs), analgesics and steroid drugs, for example, are commonly indicated for this purpose. 30,31 The administration of NSAIDs is particularly concerning because, although they effectively mitigate pain associated with severe cases of OA, their use is known to be associated with potentially serious dose-dependent gastrointestinal (GI) complications, such as upper GI bleeding. 31 Given these complicated circumstances, there is a great need for suitable interventional therapies capable of counteracting the degenerative joint microenvironment safely and efficaciously.…”

Section: Current Therapeutic Alternatives For Oamentioning

confidence: 99%

The protective role of glutathione in osteoarthritis

Setti¹,

Arab²,

Santos³

et al. 2021

Journal of Clinical Orthopaedics and Trauma

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It is currently understood that osteoarthritis (OA) is a major chronic inflammatory musculoskeletal disease. While this disease has long been attributed to biomechanical trauma, recent evidence establishes a significant correlation between osteoarthritic progression and unbridled oxidative stress, responsible for prolonged inflammation. Research describes this as a disturbance in the balanced production of reactive oxygen species (ROS) and antioxidant defenses, generating macromolecular damage and disrupted redox signaling and control. Since ROS pathways are being considered new targets for OA treatment, the development of antioxidant therapy to counteract exacerbated oxidative stress is being continuously researched and enhanced in order to fortify the cellular defenses. Experiments with glutathione and its precursor molecule, N-acetylcysteine (NAC), have shown interesting results in the literature for the management of OA, where they have demonstrated efficacy in reducing cartilage degradation and inflammation markers as well as significant improvements in pain and functional outcomes. Glutathione remains a safe, effective and overall cheap treatment alternative in comparison to other current therapeutic solutions and, for these reasons, it may prove to be comparably superior under particular circumstances. Methods: Literature was reviewed using PubMed and Google Scholar in order to bring up significant evidence and illustrate the defensive mechanisms of antioxidant compounds against oxidative damage in the onset of musculoskeletal diseases. The investigation included a combination of keywords such as: oxidative stress, oxidative damage, inflammation, osteoarthritis, antioxidant, glutathione, n-acetylcysteine, redox, and cell signaling. Conclusion:Based on the numerous studies included in this literature review, glutathione and its precursor N-acetylcysteine have demonstrated significant protective effects in events of prolonged, exacerbated oxidative stress as seen in chronic inflammatory musculoskeletal disorders such as osteoarthritis.

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“…To date, liposomes continue to be among the lipid nanocarriers that are most used for the drug delivery of hydrophilic and lipophilic compounds [18]. Among the different types of these lipid vesicles, those containing a single bilayer (unilamellar vesicles or ULV) are ideal to encapsulate hydrophilic drugs, while those containing multiple bilayers (multilamellar vesicles or MLV) are more suitable for lipophilic drugs [19].…”

Section: Introductionmentioning

confidence: 99%

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release

et al. 2018

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In this study, the encapsulation of curcumin (Cur) in “drug-in-cyclodextrin-in-liposomes (DCL)” by following the double-loading technique (DL) was proposed, giving rise to DCL–DL. The aim was to analyze the effect of cyclodextrin (CD) on the physicochemical, stability, and drug-release properties of liposomes. After selecting didodecyldimethylammonium bromide (DDAB) as the cationic lipid, DCL–DL was formulated by adding 2-hydroxypropyl-α/β/γ-CD (HPβCD)–Cur complexes into the aqueous phase. A competitive effect of cholesterol (Cho) for the CD cavity was found, so cholesteryl hemisuccinate (Chems) was used. The optimal composition of the DCL–DL bilayer was obtained by applying Taguchi methodology and regression analysis. Vesicles showed a lower drug encapsulation efficiency compared to conventional liposomes (CL) and CL containing HPβCD in the aqueous phase. However, the presence of HPβCD significantly increased vesicle deformability and Cur antioxidant activity over time. In addition, drug release profiles showed a sustained release after an initial burst effect, fitting to the Korsmeyer-Peppas kinetic model. Moreover, a direct correlation between the area under the curve (AUC) of dissolution profiles and flexibility of liposomes was obtained. It can be concluded that these “drug-in-cyclodextrin-in-deformable” liposomes in the presence of HPβCD may be a promising carrier for increasing the entrapment efficiency and stability of Cur without compromising the integrity of the liposome bilayer.

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Towards the antioxidant therapy in Osteoarthritis: Contribution of nanotechnology

Cited by 16 publications

References 109 publications

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

The protective role of glutathione in osteoarthritis

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release

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