Towards the controlled release of metal nanoparticles from biomaterials: Physico-chemical, morphological and bioactivity features of Cu-containing sol–gel glasses

Aina, Valentina; Cerrato, G.; Martra, Gianmario; Malavasi, Gianluca; Lusvardi, Gigliola; Menabue, Ledi

doi:10.1016/j.apsusc.2013.06.093

Cited by 24 publications

(19 citation statements)

References 45 publications

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“…The different release profile and higher release of Cu + 2 than Zn + 2 ions from either pure doped glass particles or composite scaffolds are due to their differences in atomic radii and electronegativities generating diverse interactions with the nonbridging oxygen of the silicate tetrahedrons from the glass network . Indeed, while Zn can strongly bind to the silicate network forming tetrahedral structures similar as Si atoms hindering its release, no evidence of CuOSi or other connections of Cu to the glass network have been found . The weaker bond of Cu within the glass structure can explain its higher release as compared with Zn ions.…”

Section: Discussionmentioning

confidence: 99%

PDLLA scaffolds with Cu‐ and Zn‐doped bioactive glasses having multifunctional properties for bone regeneration

Bejarano

Detsch

Boccaccını

et al. 2016

J Biomedical Materials Res

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Novel multifunctional scaffolds for bone regeneration can be developed by incorporation of bioactive glasses (BG) doped with therapeutic and antibacterial metal ions, such as copper (Cu) and zinc (Zn), into a biodegradable polymer. In this context, porous composite materials of biodegradable poly(d, l-lactide) (PDLLA) mixed with sol-gel BG of chemical composition 60SiO ; 25CaO; 11Na O; and 4P O (mol %) doped with either 1 mol % of CuO or ZnO, and with both metals, were prepared. The cytocompatibility of the scaffolds on bone marrow stromal cells (ST-2) depended on both, the amount of glass filler and the concentration of metal ion, as evaluated by lactate dehydrogenase (LDH) activity, cell viability (water-soluble tetrazolium salt [WST-8]), and by cell morphology (scanning electron microscopy [SEM]) tests. In particular, scaffolds having a filler content of 10 wt % showed the highest cytocompatibility. In addition, compared to the neat polymer, the scaffolds containing Cu promoted the angiogenesis marker (Vascular endothelial growth factor concentration) to a larger extent while scaffolds containing Zn increased the osteogenesis marker (specific alkaline phosphatase-activity). Noteworthy, the scaffolds with both metal ions showed a combined effect on both properties. Cu- and Zn-doped glasses also provided higher antibacterial capacity to PDLLA-based scaffolds against methicillin-resistant S. aureus bacteria than undoped glass. In combination, our results showed that by a proper addition of Cu- and Zn-doped BG to a PDLLA matrix, multifunctional composite scaffolds with enhanced biological activity can be designed for bone tissue regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 746-756, 2017.

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Section: Discussionmentioning

confidence: 99%

PDLLA scaffolds with Cu‐ and Zn‐doped bioactive glasses having multifunctional properties for bone regeneration

Bejarano

Detsch

Boccaccını

et al. 2016

J Biomedical Materials Res

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“…The presence of Cu in the 58S glass decreased the ability to form surface crystalline apatites for all percentages of metal incorporated (figure 5(a)) as concluded by the lower intensity of the HA peaks after immersion in SBF. The competition between Cu +2 and Ca +2 ions in solution for the precipitation of phosphate species can explain the lower bioactivity of the doped glasses [25,35]. For the incorporation of Cu in the NaBG glass ( figure 5(b)) otherwise did not significantly affected the formation of HA.…”

Section: Apatite-forming Ability and Dissolution After Soaking In Sbfmentioning

confidence: 98%

Sol–gel synthesis and in vitro bioactivity of copper and zinc-doped silicate bioactive glasses and glass-ceramics

Bejarano¹,

Caviedes²,

Palza³

2015

Biomed. Mater.

122

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Metal doping of bioactive glasses based on ternary 60SiO2-36CaO-4P2O5 (58S) and quaternary 60SiO2-25CaO-11Na2O-4P2O5 (NaBG) mol% compositions synthesized using a sol-gel process was analyzed. In particular, the effect of incorporating 1, 5 and 10 mol% of CuO and ZnO (replacing equivalent quantities of CaO) on the texture, in vitro bioactivity, and cytocompatibility of these materials was evaluated. Our results showed that the addition of metal ions can modulate the textural property of the matrix and its crystal structure. Regarding the bioactivity, after soaking in simulated body fluid (SBF) undoped 58S and NaBG glasses developed an apatite surface layer that was reduced in the doped glasses depending on the type of metal and its concentration with Zn displaying the largest inhibitions. Both the ion release from samples and the ion adsorption from the medium depended on the type of matrix with 58S glasses showing the highest values. Pure NaBG glass was more cytocompatible to osteoblast-like cells (SaOS-2) than pure 58S glass as tested by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The incorporation of metal ions decreased the cytocompatibility of the glasses depending on their concentration and on the glass matrix doped. Our results show that by changing the glass composition and by adding Cu or Zn, bioactive materials with different textures, bioactivity and cytocompatibility can be synthesized.

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“…By introducing Cu in the glass structure, one can obtain materials with angiogenesis response and with antibacterial activity. The presence of Cu metal as Cu n + species on surface of the glass can be also used to bind different biomolecules in order to obtain drug delivery systems [ 121 ].…”

Section: Metallic Nanoparticles In Composites With Bioactive Glassmentioning

confidence: 99%

“…Several studies revealed that CuNPs containing silicate glasses did not show any bioactivity alteration [ 120 , 121 , 122 ]. The antibacterial activity of silicate glass with Cu has been demonstrated by Popescu et al [ 122 ] by obtaining samples with good antibacterial effects against Staphylococcus aureus .…”

Section: Metallic Nanoparticles In Composites With Bioactive Glassmentioning

confidence: 99%

Surface Plasmon Resonance or Biocompatibility—Key Properties for Determining the Applicability of Noble Metal Nanoparticles

et al. 2017

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Metal and in particular noble metal nanoparticles represent a very special class of materials which can be applied as prepared or as composite materials. In most of the cases, two main properties are exploited in a vast number of publications: biocompatibility and surface plasmon resonance (SPR). For instance, these two important properties are exploitable in plasmonic diagnostics, bioactive glasses/glass ceramics and catalysis. The most frequently applied noble metal nanoparticle that is universally applicable in all the previously mentioned research areas is gold, although in the case of bioactive glasses/glass ceramics, silver and copper nanoparticles are more frequently applied. The composite partners/supports/matrix/scaffolds for these nanoparticles can vary depending on the chosen application (biopolymers, semiconductor-based composites: TiO2, WO3, Bi2WO6, biomaterials: SiO2 or P2O5-based glasses and glass ceramics, polymers: polyvinyl alcohol (PVA), Gelatin, polyethylene glycol (PEG), polylactic acid (PLA), etc.). The scientific works on these materials’ applicability and the development of new approaches will be targeted in the present review, focusing in several cases on the functioning mechanism and on the role of the noble metal.

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Towards the controlled release of metal nanoparticles from biomaterials: Physico-chemical, morphological and bioactivity features of Cu-containing sol–gel glasses

Cited by 24 publications

References 45 publications

PDLLA scaffolds with Cu‐ and Zn‐doped bioactive glasses having multifunctional properties for bone regeneration

PDLLA scaffolds with Cu‐ and Zn‐doped bioactive glasses having multifunctional properties for bone regeneration

Sol–gel synthesis and in vitro bioactivity of copper and zinc-doped silicate bioactive glasses and glass-ceramics

Surface Plasmon Resonance or Biocompatibility—Key Properties for Determining the Applicability of Noble Metal Nanoparticles

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