Towards the development of a DNA automaton: modular RNA-cleaving deoxyribozyme logic gates regulated by miRNAs

Smirnov, Viktor V.; Drozd, Valerya S.; Patra, Christina K.; Hussein, Zain; Rybalko, Daria S.; Kozlova, Anastasia V.; Nour, Moustapha A. Y.; Zemerova, Tatiana P.; Kolosova, Olga S.; Kalnin, Arseniy Y.; El-Deeb, Ahmed A.

doi:10.1039/d3an02178e

Analyst

2024

DOI: 10.1039/d3an02178e

|View full text |Cite

Towards the development of a DNA automaton: modular RNA-cleaving deoxyribozyme logic gates regulated by miRNAs

Viktor V. Smirnov,

Valerya S. Drozd,

Christina K. Patra

et al.

Abstract: Advancements in DNA computation have unlocked molecular-scale information processing possibilities, utilizing the intrinsic properties of DNA for complex logical operations with transformative applications in biomedicine. DNA computation shows promise in...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines

Hussein,

Golovina,

Alaji

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

show abstract

Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines

Hussein,

Golovina,

Alaji

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

show abstract

Marker‐Dependent Cleavage of RNA by Binary (split) DNAzyme (BiDz) and Binary DNA Machines (BiDM)

Dubovichenko,

Nedorezova,

Patra

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

Oligonucleotide gene therapy (OGT) can be used to suppress specific RNA in cells and thus have been explored for gene therapy. Despite extensive effort, there is no clinically significant OGT for treating cancer. Low efficiency of OGT is one of the problems. Earlier, we proposed to address this problem by suppressing most vital genes in cancer cells e.g. housekeeping genes. To achieve specific activation of the OGT agents in cancer but not in normal cells, we designed binary (split) DNAzyme (BiDz), which is activated by cancer‐related nucleic acid sequences. This work is devoted to BiDz optimization using cancer marker‐related sequence as an activator and three folded RNA targets. To achieve efficient binding of folded RNA, the BiDz design was equipped with RNA binding/unwinding arms, a construction that was dabbed ‘BiDz machines’ (BiDM). BiDM was designed to have improved both iRNA cleavage rates and RNA recognition in comparison with BiDz. Further development of DNA nanotechnology‐inspired agents can advance OGT technology in treating cancer, viral infections, and genetic disorders.

show abstract

An electrochemical biosensor equipped with a logic circuit as a smart automaton for two-miRNA pattern detection

Xie,

Du,

Gao

et al. 2024

Analyst

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Towards the development of a DNA automaton: modular RNA-cleaving deoxyribozyme logic gates regulated by miRNAs

Abstract: Advancements in DNA computation have unlocked molecular-scale information processing possibilities, utilizing the intrinsic properties of DNA for complex logical operations with transformative applications in biomedicine. DNA computation shows promise in...

Cited by 3 publications

References 45 publications

Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines

Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines

Marker‐Dependent Cleavage of RNA by Binary (split) DNAzyme (BiDz) and Binary DNA Machines (BiDM)

An electrochemical biosensor equipped with a logic circuit as a smart automaton for two-miRNA pattern detection

Contact Info

Product

Resources

About