Towards the Development of Antioxidant Cerium Oxide Nanoparticles for Biomedical Applications: Controlling the Properties by Tuning Synthesis Conditions

Gallucci, Noemi; Vitiello, Giuseppe; Girolamo, Rocco Di; Imbimbo, Paola; Monti, Daria Maria; Tarallo, Oreste; Vergara, Alessandro; Krauss, Irene Russo; Paduano, Luigi

doi:10.3390/nano11020542

Cited by 31 publications

(14 citation statements)

References 68 publications

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“…The scattered intensity correlation function was analyzed using a regularization algorithm [ 22 ]. The diffusion coefficient of each population of diffusing particles was calculated as the z-average of the diffusion coefficients of the corresponding distributions [ 23 , 24 , 25 ]. The culture media used for NP biosynthesis were taken as blanks.…”

Section: Methodsmentioning

confidence: 99%

Extremophilic Microorganisms for the Green Synthesis of Antibacterial Nanoparticles

et al. 2022

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The biogenic synthesis of nanomaterials, i.e., synthesis carried out by means of living organisms, is an emerging technique in nanotechnology since it represents a greener and more eco-friendly method for the production of nanomaterials. In this line, in order to find new biological entities capable of biogenic synthesis, we tested the ability of some extremophilic microorganisms to carry out the biogenic production of AgNPs and SeNPs. Silver NPs were produced extracellularly by means of the thermophilic Thermus thermophilus strain SAMU; the haloalkaliphilic Halomonas campaniensis strain 5AG was instead found to be useful for the synthesis of SeNPs. The structural characterization of the biogenic nanoparticles showed that both the Ag and Se NPs possessed a protein coating on their surface and that they were organized in aggregates. Moreover, both types of NPs were found be able to exert an interesting antibacterial effect against either Gram-positive or Gram-negative species. This study confirmed that extremophilic microorganisms can be considered valuable producers of biologically active nanoparticles; nevertheless, further experiments must be performed to improve the synthesis protocols in addition to the downstream processes.

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Section: Methodsmentioning

confidence: 99%

Extremophilic Microorganisms for the Green Synthesis of Antibacterial Nanoparticles

et al. 2022

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“…Due to the special electronic configuration and reversible switching between oxidation states (Ce +3 and Ce +4 ), it is an attractive material for many applications, such as UV absorption, fuel cells, fuel oxidation, catalysis, polishing and others [ 161 , 162 , 163 , 164 ]. In the biomedical field, cerium oxide NPs have attracted special interest due to their regenerative and multi-enzymatic properties for ROS scavenging [ 163 , 165 ]. Bulk cerium oxide mainly consists of Ce +4 , whereas in nano form, a considerable amount of Ce +3 is present, which enhances its catalytic properties and biological role [ 166 , 167 ].…”

Section: Doped Cerium and Nanodot-encrusted Structuresmentioning

confidence: 99%

“…In the biomedical field, cerium oxide NPs have attracted special interest due to their regenerative and multi-enzymatic properties for ROS scavenging [163,165]. Bulk cerium oxide mainly consists of Ce +4 , whereas in nano form, a considerable amount of Ce +3 is present, which enhances its catalytic properties and biological role [166,167].…”

Section: Doped Cerium and Nanodot-encrusted Structuresmentioning

confidence: 99%

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

et al. 2022

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The development of smart, efficient and multifunctional material systems for diseases treatment are imperative to meet current and future health challenges. Nanomaterials with theranostic properties have offered a cost effective and efficient solution for disease treatment, particularly, metal/oxide based nanotheranostic systems already offering therapeutic and imaging capabilities for cancer treatment. Nanoparticles can selectively generate/scavenge ROS through intrinsic or external stimuli to augment/diminish oxidative stress. An efficient treatment requires higher oxidative stress/toxicity in malignant disease, with a minimal level in surrounding normal cells. The size, shape and surface properties of nanoparticles are critical parameters for achieving a theranostic function in the microenvironment. In the last decade, different strategies for the synthesis of biocompatible theranostic nanostructures have been introduced. The exhibition of therapeutics properties such as selective reactive oxygen species (ROS) scavenging, hyperthermia, antibacterial, antiviral, and imaging capabilities such as MRI, CT and fluorescence activity have been reported in a variety of developed nanosystems to combat cancer, neurodegenerative and emerging infectious diseases. In this review article, theranostic in vitro behaviour in relation to the size, shape and synthesis methods of widely researched and developed nanosystems (Au, Ag, MnOx, iron oxide, maghemite quantum flakes, La2O3−x, TaOx, cerium nanodots, ITO, MgO1−x) are presented. In particular, ROS-based properties of the nanostructures in the microenvironment for cancer therapy are discussed. The provided overview of the biological behaviour of reported metal-based nanostructures will help to conceptualise novel designs and synthesis strategies for the development of advanced nanotheranostic systems.

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“…The sample was prepared at a concentration of 20 mg/L. DLS measurements were performed using a home-made instrument, composed of a Photocor compact goniometer, an SMD 6000 Laser Quantum 50 mW light source (Quantum Laser Ltd., Stockport, UK) operating at 532.5 nm, a photomultiplier (PMT-120-OP/B), and a correlator (Flex02-01D) from Correlator.com (http://correlator.com/cgi-sys/, accessed on 6 November 2021) [29][30][31]. All measurements were performed at 25 • C, with the temperature controlled through a thermostatic bath, and at fixed angle θ = 90 • .…”

Section: Dynamic Light Scattering (Dls)mentioning

confidence: 99%

Comparative Toxicological Evaluation of Tattoo Inks on Two Model Organisms

Carotenuto

Fogliano

Rienzi

et al. 2021

Biology

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Tattooing is a technique that introduces colored substances under the skin in order to color it permanently. Decomposition products of tattoo pigments produce numerous damages for the skin and other organs. We studied the effects of a commercial red ink tattoo, PR170, on Xenopus laevis embryos and Daphnia magna nauplii using concentrations of 10, 20, and 40 mg/L. For Xenopus, we applied the FETAX protocol analyzing survival, malformations, growth, heart rate, and the expression of genes involved in the development. In D. magna, we evaluated the toxicity with an immobilization test. Moreover, we investigated the production of ROS, antioxidant enzymes, and the expression of the ATP-binding cassette in both models. Our results indicate that PR170 pigment has nanoparticle dimensions, modifies the survival and the ATP-binding cassette activity, and induces oxidative stress that probably produces the observed effects in both models. Deformed embryos were observed in Xenopus, probably due to the modification of expression of genes involved in development. The expression of pro-inflammatory cytokines was also modified in this amphibian. We think that these effects are due to the accumulation of PR170 and, in particular, to the presence of the azoic group in the chemical structure of this pigment. Further studies needed to better understand the effects of commercial tattoo inks.

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Towards the Development of Antioxidant Cerium Oxide Nanoparticles for Biomedical Applications: Controlling the Properties by Tuning Synthesis Conditions

Cited by 31 publications

References 68 publications

Extremophilic Microorganisms for the Green Synthesis of Antibacterial Nanoparticles

Extremophilic Microorganisms for the Green Synthesis of Antibacterial Nanoparticles

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

Comparative Toxicological Evaluation of Tattoo Inks on Two Model Organisms

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