Towards the Ophthalmology Patentome: a Comprehensive Patent Database of Ocular Drugs and Biomarkers

Abstract

We are currently building a database of all patent documents that contain substantial information related to pharmacology, drug delivery, tissue technology, and molecular diagnostics in ophthalmology. The goal is to establish a 'patentome', a body of cleaned and annotated data where all text-based, chemistry and pharmacology information can be accessed and mined in its context. We provide metrics on patent convention treaty documents, which demonstrate that ocular-related patenting has shown stronger growth than general patent cooperation treaty patenting during the past 25 years, and, while the majority of applications of this type have always provided substantial biological data, both data support and objections by patent examiners have been increasing since 2006-2007. Separately, we present a case study of chemistry information extraction from patents published during the 1950s and 1970s, which reveal compounds with corneal anesthesia potential that were never published in the peer-reviewed literature.

FPR2/ALXR Agonists and the Resolution of Inflammation

“…180 Both patents were reviewed later, and examples 53 and 54 were described in the literature with a comment indicating that these patents are a clear indication that FPR2/ ALXR is an emerging potential therapeutic target. 181 The replacement of the central pyrazole or triazole was the object a follow-up patent covering oxazole and thiazole derivatives of formula IX, with 55 (Figure 23) as the most active compound with a FPR2/ALXR EC 50 Ca 2+ of 0.3 nM. 182 The modifications of the extremities of the triazole-based FPR2/ALXR agonists were exemplified in a series of follow-up patents.…”