2006
DOI: 10.1016/j.copbio.2006.02.005
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Towards understanding molecular modes of probiotic action

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Cited by 289 publications
(200 citation statements)
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“…Both studies suggested that the pH-lowering effects of the probiotic appeared to be important for enabling these anti-infectious activities. Furthermore, B. breve strains have been reported to display antimicrobial activity against pathogens through competitive exclusion (Lievin et al, 2000), whereby probiotic strains with similar adherence mechanisms inhibit the attachment and colonization of the pathogen at these binding sites, thus protecting the host from infection (Marco et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Both studies suggested that the pH-lowering effects of the probiotic appeared to be important for enabling these anti-infectious activities. Furthermore, B. breve strains have been reported to display antimicrobial activity against pathogens through competitive exclusion (Lievin et al, 2000), whereby probiotic strains with similar adherence mechanisms inhibit the attachment and colonization of the pathogen at these binding sites, thus protecting the host from infection (Marco et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…They are important components of the gut microbiota, and they may be present at concentrations of 10 9 210 11 cells per g faeces, representing the majority of the microbial gut population in the colon during the early stage of life (Harmsen et al, 2000;Langendijk et al, 1995). Furthermore, bifidobacteria are target species for prebiotics, and some strains are known to beneficially modulate several host-cell functions, the most prevalent of which are the immune responses and intestinal barrier integrity, although the molecular basis of these promoting effects is still largely unknown (Marco et al, 2006;Salminen et al, 2005). For all these reasons, these micro-organisms are attractive probiotic candidates for inclusion in functional food products, normally being consumed as adjunct cultures in fermented dairy products (Masco et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…With a targeted use of specific probiotic strains, it is possible to induce an immune stimulant type of response on both B (increase of humoral immunity) and T lymphocytes (increase of cell-mediated immunity) and on the phagocytic component, particularly on polymorphonuclear cells [37,38]. The ability to stimulate responses of this type is useful in very specific clinical circumstances, for example for immunoprophylaxis of upper respiratory tract infections during winter or, in addition to influenza vaccination, to increase antibody response to vaccine or, more generally, to increase nonspecific immunity surveillance to pathogens of different nature [39,40].…”
Section: Probiotics and The Immune Responsementioning
confidence: 99%