Towards understanding topological features of protein interactome map of muscle cancer

Abstract

Muscle cancer despite being rare but it is important for more examination due to its high mortality risk. Here, applying protein-protein interaction PPI network, we analyzed proteins that are related to this neoplasm in more details. The String Database (db) as the source for network was used through Cytoscape 3.4. The centrality examination by Network Analyzer, Cytoscape plug-in is done. The findings indicate that there are some proteins with higher linkage to the disease and with central topological features. These hub-bottlenecks are TP53, AKT1, MYC, and KIT. The prioritized proteins in this analysis indicate that these molecules may have prominent role in interactome of muscle cancer; however, more investigation is required to establish this claim.