2019
DOI: 10.1155/2019/7595126
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Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung

Abstract: Clinical studies have demonstrated a strong association between both acute toxic exposure and the repetitive, chronic exposure to acetaminophen (APAP) with pulmonary dysfunction. However, the mechanisms underlying this association are unknown. Preclinical reports have demonstrated that significant bronchiolar injury occurs with toxic APAP exposure, but very little information exists on how the distal lung is affected. However, cells in the alveolar space, including the pulmonary epithelium and resident macroph… Show more

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Cited by 12 publications
(5 citation statements)
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“…Despite the anatomical and physiological differences between mice and humans, murine models are often used in pulmonary research to study fibrosis, 1-3 chronic obstructive pulmonary disease, 4 hypoplasia, 5 eosinophilic granulomatous polyangiitis 6 and toxic acetaminophen exposure. 7 Analytical technologies provide insight into lung diseases, in both humans and murine models, enabling the potential translation of knowledge and applications to human disease. 8 Overall, the investigation of these murine models has improved the understanding of the underlying biology and pathogenesis in human lung diseases.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Despite the anatomical and physiological differences between mice and humans, murine models are often used in pulmonary research to study fibrosis, 1-3 chronic obstructive pulmonary disease, 4 hypoplasia, 5 eosinophilic granulomatous polyangiitis 6 and toxic acetaminophen exposure. 7 Analytical technologies provide insight into lung diseases, in both humans and murine models, enabling the potential translation of knowledge and applications to human disease. 8 Overall, the investigation of these murine models has improved the understanding of the underlying biology and pathogenesis in human lung diseases.…”
Section: Introductionmentioning
confidence: 99%
“…Currently, there are various technologies that can visualize analytes in ex vivo lung samples. These include Masson's trichrome and hematoxylin and eosin (H&E) staining for histopathology, [1][2][3][4]6,7 immunohistochemistry and immunofluorescence for detecting cellular protein abundances, 5,7 ex vivo computed tomography (CT) for regional quantitative analysis of targeted fluorescent substances 10 and tissuecleared light sheet fluorescence microscopy for precise cellular-level mapping of targeted analytes. 10 While most of these techniques offer high spatial resolution at the cellular level, CT scans provide the additional benefit of three-dimensional scanned images, however, they do not provide molecular information.…”
Section: Introductionmentioning
confidence: 99%
“…The endoplasmic reticulum (ER) plays an important role in cellular protein synthesis and processing, as well as maintaining intracellular stability [ 8 , 9 ]. In ER stress (ERS), as a result of disruption of ER homeostasis protein folding is compromised, which has been found to be associated with serious pathological processes, including hypoxia, starvation, and calcium imbalance [ 10 , 11 ]. ER stress has also been confirmed in patients with sepsis.…”
Section: Introductionmentioning
confidence: 99%
“…Among the various biochemical mechanisms and signal pathways that may be involved [12][13][14], endoplasmic reticulum (ER) stress has been found to be associated with reperfusion-mediated oxidative stress and cardiomyocyte death [15,16]. ER stress refers to a pathological process associated with hypoxia, starvation, calcium imbalance, and free radical overproduction that disrupts the physiological functions of the ER [17,18]. These stimuli may cause signaling from the ER to the cytoplasm and nucleus, where adaptive responses or the apoptotic program will be ultimately activated [19,20].…”
Section: Introductionmentioning
confidence: 99%