Toxic chemicals, including aromatic and chlorinated hydrocarbons and their derivatives, and liver lesions in white croaker (Genyonemus lineatus) from the vicinity of Los Angeles

Relationships between toxicopathic hepatic lesions and exposure to chemical contaminants in English sole (Pleuronectes vetulus), starry flounder (Platichthys stellatus), and white croaker (Genyonemus lineatus) from selected marine sites on the Pacific Coast, USA.

“…Chemical risk factors were rarely and inconsistently identified for the nonspecific necrotic lesions, represented primarily by hepatocellular coagulative necrosis. Although this lesion is regarded as a potential biomarker of contaminant exposure in wild fish that needs further confirmation (2), inconsistent statistical associations have been shown between this lesion category in several species and contaminant exposure in field studies conducted by our group (20,21,24). In this study, the only risk factor common to more than one species (sole and croaker) was hepatic bioaccumulation of XDDTs; there were no other risk factors in sole.…”

“…The discussion below interprets the toxicological significance, to the extent possible, of the complex associations between lesion types and measures of potential contaminant exposure, actual dietary uptake, hepatic Volume 102, Number 2, February 1994 aAnalyses were performed separately while adjusting for mean age and gender ratio (female:male). (2,10-12, 75,76) and which significantly co-occur with neoplasms in English sole (18) (3,15,24,25,39,59), in studies in other species of wild fish (69,77,78) and the hepatocarcinogenicity of genotoxic PAHs in laboratory studies with fish (5,41,42,(79)(80)(81). XPAHs in sediment from English sole sites ranged from undetectable at the Nisqually River reference site to 5900 ng/g in Elliott Bay, comparable to levels in previous studies where the relationship between PAH exposure and neoplasms was first established in this species (15).…”

“…Moreover, megalocytic hepatosis significantly co-occurs with hepatocellular regeneration in individual English sole (18). These lesions are regarded as reliable biomarkers of contaminant exposure in wild fish (2), including English sole (18)(19)(20)34) and white croaker (20,24 (8,101,106,10) and fish (108) can induce similar hepatic lesions.…”

Effect of polychlorinated biphenyls (Delor 103) on haematological and enzyme parameters of the rainbow trout Oncorhynchus mykiss

“…This is why great attention is paid to PCBs from the hygienic and toxicological points of view (Hajšlová et al 1997(Hajšlová et al , Ř ehulka 2001(Hajšlová et al , 2002a. PCBs have adverse effects on the state of fish health (Hinton et al 1978, Malins et al 1987Myers et al 1987, Svobodová et al 1994) and on the endocrine system mainly in the area of the reproductive function of fish (Nelson 1974, Janssen et al 1995. Bio-concentration factors (BCFs) in aquatic animals ranging from 26 000 to 66 000 have been shown experimentally (ATSDR/TP-92/16 1993).…”

Terrestrial Wildlife Exposed to Agrochemicals: An Ecological Risk Assessment Perspective

“…Food re- Physiological. Differences in physiological parameters such as body weight, organ weight [66], body measurements, body temperature, heart rate, fat content, and tissue histopathology [81,82] or the presence of physiological deformities can be used as a measure of exposure to pesticides and other toxic chemicals. Expected impairments and measurements will be a function of the basic toxicity of the on-site compounds and patterns of exposure.…”