Toxic contamination of nutraceuticals and food ingredients

Gil, Fernando; Hernández, Antonio F.; Martín-Domingo, M. Concepción

doi:10.1016/b978-0-12-821038-3.00068-9

Cited by 5 publications

(3 citation statements)

References 97 publications

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“…Nutraceuticals can be toxic to consumers if they become contaminated with heavy metals, metalloids, mycotoxins, allergens, fertilizers, pesticides or non-product residues from toxic plants during production. The risk of adverse pharmacokinetic or pharmacodynamic interactions between nutraceuticals and therapeutics can occur [93,94], which is worrying considering that patients rarely disclose their consumption of supplements to their physicians [95]. Indeed, several common examples exist.…”

Section: Concerns Regarding Nutraceutical Safety and Efficacymentioning

confidence: 99%

The current use and evolving landscape of nutraceuticals

Chopra¹,

Lordan²,

Horbańczuk

et al. 2022

Pharmacological Research

120

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Section: Concerns Regarding Nutraceutical Safety and Efficacymentioning

confidence: 99%

The current use and evolving landscape of nutraceuticals

Chopra¹,

Lordan²,

Horbańczuk

et al. 2022

Pharmacological Research

120

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“…Nutraceutical contamination can occur during any stage of production with pesticides, heavy metals and metalloids, mycotoxins, and radioactivity, or adulterated with drugs, with alterations in quality and safety. The population and healthcare professionals should be better informed regarding the concept and usefulness of nutraceuticals and regarding the potential adverse effects associated with their possible contamination [192].…”

Section: Weaknessmentioning

confidence: 99%

Nutraceutical Benefits for Bone Health: Role in Osteoporosis Prevention

Roseti,

Borciani,

Grassi

et al. 2023

Preprint

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Osteoporosis is characterized by low bone mass and structural deterioration of bone tissue with increased risk of fracture. The population that is most at risk for primary osteoporosis in-cludes post-menopausal women. Among different approaches, nutraceuticals are increasingly popular in developed countries since can contribute to bone health and can delay the onset of pathological bone loss. Our review covers three main aspects. Firstly, we discuss the current state of the two con-ditions, osteopenia, and osteoporosis. Secondly, we focus on the latest developments in natural Nutraceuticals and their effectiveness in reducing bone loss. Finally, we conduct a Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis to examine the pros and cons of Nutraceuticals assumption. Nutraceuticals hold great promise, but we must address challenges such as regulatory control and experimental evidence to fully realize their potential. Other challenges include identifying the source of raw materials, ensuring the purity of the compound, avoiding contamination or the presence of other active compounds, maintaining product quality, and preventing interactions with other elements or drugs. By addressing these challenges, the scientific community can ensure more reliable indica-tions for the use of Nutraceuticals and help people lead healthier lives.

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“…[11] Heavy metals' toxicity includes liver disorder, immune function disorder, cancer, cardiovascular toxicity, neurological disorders, hepatic and renal dysfunction. [11][12] Toxicities of nutraceutical ingredients include spontaneous bleeding after prolonged exposure of high dose Ginkgo biloba, increased risk of hypercalcemia due to the interaction of calcium and vitamin D supplements with digoxin/thiazide diuretics; carcinoma, hepatotoxicity, genotoxicity, and mutagenicity associated with St. John's wort (Hypericum perforatum), cinnamon and Aloe vera. [11,13] Further, the response of nutraceuticals varies from individual to individual; hence, in order to gain maximum therapeutic benefit and to avoid any significant adverse effects, nutraceuticals must be consumed in recommended dosages set out by regulatory agencies; and should be free from /or within the tolerance limits of contaminants set out by the agencies.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Qualitative Assessment of Marketed Nutraceuticals for Active Ingredients and Heavy Metals for Safety and Efficacy

Dhiman¹,

Bansal²

2022

Int. J. Pharm. Sci. Drug Res.

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The global nutraceutical market is expanding fast, and people nowadays are inclined towards nutraceutical supplements for daily micronutrient needs and health benefits in some disease conditions. Hence, ensuring the safe and effective use of these supplements is the need of the hour. The current study is aimed at determining the accuracy and regulatory compliance of marketed nutraceutical formulations by quantifying the active nutraceutical ingredients and heavy metal content in these formulations using advanced analytical techniques. Total 12 marketed formulations were selected and analyzed in NABL (National Accreditation Board for Testing and Calibration Laboratories) accredited laboratory using High-performance liquid chromatography (HPLC) and inductively coupled plasma-mass-spectrometry (ICP-MS). The quantified values were compared with label-stated values and recommended values as per FSSAI. The quantified values in two lycopene samples varied significantly (-16 and +16%) from the label stated content and were found non-compliant with the regulatory recommendations. The measured intake values of calcium and vitamin D varied from 24 to 204% from the recommended daily allowances established by FSSAI. The quantified daily intake values varied from 4.2 to 58 mg and from 4 to 21.5 mg for lycopene and lutein, respectively. Heavy metal content determination resulted in two samples deviating from the tolerance limits of heavy metals for lead and arsenic. The mean values for lead and arsenic were found to be 2.482 ± 6.921 and 0.311 ± 0.655 ppm, respectively. The present study results provided vital information on the composition of marketed nutraceutical formulations. The regulatory agencies require stringent monitoring practices to ensure compliance with the existing regulatory guidelines to provide the consumer safe and effective nutraceutical products.

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Toxic contamination of nutraceuticals and food ingredients

Cited by 5 publications

References 97 publications

The current use and evolving landscape of nutraceuticals

The current use and evolving landscape of nutraceuticals

Nutraceutical Benefits for Bone Health: Role in Osteoporosis Prevention

Quantitative and Qualitative Assessment of Marketed Nutraceuticals for Active Ingredients and Heavy Metals for Safety and Efficacy

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