2020
DOI: 10.1016/j.envpol.2020.114857
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Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones

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Cited by 54 publications
(24 citation statements)
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“…Aside from cardiac chemical response, network analysis has also been used to better understand heart regeneration in zebrafish [ 61 ]. Additional network analysis focused on Weighted gene co-expression network analysis (WGCNA) has also been applied to zebrafish, but again focusing on a smaller and more chemically homogenous dataset allowing for a detailed analysis of these chemicals and responses [ 62 ]. Our inclusion here of a large number of chemicals that show a range of phenotypic and transcriptomic responses lead a more comprehensive network that can highlight many different pathways and processes.…”
Section: Discussionmentioning
confidence: 99%
“…Aside from cardiac chemical response, network analysis has also been used to better understand heart regeneration in zebrafish [ 61 ]. Additional network analysis focused on Weighted gene co-expression network analysis (WGCNA) has also been applied to zebrafish, but again focusing on a smaller and more chemically homogenous dataset allowing for a detailed analysis of these chemicals and responses [ 62 ]. Our inclusion here of a large number of chemicals that show a range of phenotypic and transcriptomic responses lead a more comprehensive network that can highlight many different pathways and processes.…”
Section: Discussionmentioning
confidence: 99%
“…The same group also showed that epidermal exposure to benzophenone-3 damages neurons, which is associated with increase in the extracellular glutamate levels and lipid peroxidation (Pomierny et al, 2019;Skórkowska et al, 2020). Benzophenone-3 has also been shown to interfere with the nervous system by regulating the calcium signaling pathway (Meng et al, 2020). An article by Philippat and others (Philippat et al, 2017) confirms the neurodevelopmental dysfunction caused by benzophenone-3, since boys aged 3 and 5 were shown to exhibit behavioral disorders in response to prenatal exposure to this UV filter.…”
Section: Benzophenone-3 Induces Neurotoxicity Induces Apoptotic Processes and Inhibits Autophagymentioning
confidence: 98%
“…The latest data from zebrafish show that benzophenone-3 affects estradiol biosynthesis, sex differentiation and gonadotropin-releasing hormone levels. Moreover, benzophenone-3 upregulates the expression of cytochrome P450 genes and glutathione metabolism-related genes (Meng et al, 2020). Presumably, ben-zophenone-3 is also partially responsible for a significant decrease in the levels of the hormones fT3, fT4 and T4, which results in thyroid dysfunction in both men and women (Aker et al, 2016;Kim et al, 2017).…”
Section: Effects Of Benzophenone-3 On the Endocrine Systemsmentioning
confidence: 99%
“…Another controversial topic is the environmental impact of sunscreen, especially organic UVR filters and their toxic effects on marine ecosystems and aquatic organisms. [75][76][77][78] The chronic effects of common sunscreen UV filters and preservatives were tested on the photosynthetic efficiency of scleractinian coral and several organic UV filters showed no significant decrease in coral photosynthetic efficiency and hence were not likely to cause coral bleaching, but zinc oxide was more toxic. 79 To put these concerns into perspective we would like to emphasize that the major cause for coral bleaching is global warming and the concomitant increase in water temperature, although oxybenzone may further weaken coral experiencing global warming.…”
Section: Is Sunscreen Photoprotection Deleterious For the Environment?mentioning
confidence: 99%