Toxic effects of bis(thiosemicarbazone) compounds and its palladium(II) complexes on herpes simplex virus growth

Tiossemicarbazonas: métodos de obtenção, aplicações sintéticas e importância biológica

“…Atividade anti HIV também foi relatada para tiossemicarbazonas por Teitz e colaboradores Genova e colaboradores 86 , por outro lado, compararam a atividade inibitória da benzil bis (tiossemicarbazona) e seu respectivo complexo metálico de paládio(II) sobre linhagens de vírus do tipo HSV 1 e 2 (herpes simples 1 e 2) e observaram que o complexo metálico exibe melhora significativa na atividade antiviral em comparação com a tiossemicarbazona livre (Figura 3c).…”

Synthesis, Characterization and X‐ray Structures of [α‐Diphenylethanedione bis(4‐ethylthiosemicarbazonato)]palladium(II) and 1,2,4‐Triazine‐3‐thione–Zinc(II) Complexes Obtained by Metal‐Induced Cyclization

“…[1][2][3] Thiosemicarbazone derivatives have raised considerable interest in chemistry and biology because of the antibacterial, antiviral and antitumor activity that many of them have shown. [4,5] In some cases, the highest activity is associated with a metal complex rather than the free thiosemicarbazone. [6] It is well known that thiosemicarbazones derived from 1,2-dicarbonyl compounds easily cyclize during the synthesis process, especially when hydroxylic solvents are used or when solutions in such solvents are allowed to crystallize over several days.…”

Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)2]

“…The angle values are 92.25 (15) for N 4 ePdeN 1 and 87.75 (15) [40]. Another structural parameter of interest is the quasi-linearity and the asymmetry observed for the NeN distances in the azido group coordinated to palladium atom (N 1 eN 2 eN 3 ¼ 174.59 (6) , N 1 eN 2 ¼ 1.130 (7) A and N 2 eN 3 ¼ 1.180 (7) A).…”

“…Despite the fact that antitumor [11], antibacterial [12], antitrypanosomal [13], antifungal [14], antiherpetic [15], anti-inflammatory [16], antiamoebic [17] and anti-tubercular properties [18] of palladium(II) compounds have been the subject of many reports, studies on the biological activity of isonicotinamide-based Pd(II) complexes remain unknown in literature.…”