Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice

Abstract

Abstract:The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.