2021
DOI: 10.2174/1570159x19666210803150023
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Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders

Abstract: : Methamphetamine (Meth) abuse presents a worldwide problem and commonly occurs with stress and/or alcohol use disorders. Regardless, the biological causes and consequences of these co-morbidities are unclear. Whereas the mechanisms of Meth, stress and alcohol abuse have been examined individually and well-characterized, these processes overlap significantly and can impact the neural and peripheral consequences of Meth. This review focuses on the deleterious cardio- and cerebrovascular effects of Meth, stres… Show more

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Cited by 5 publications
(2 citation statements)
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“…A growing number of studies have suggested that glycerophospholipid metabolites could serve as markers for the assessment of drug addiction [33,49,50], and our ndings demonstrated that this recommendation is equally applicable to MA addiction. Previous studies have shown that direct damage from MA exposure is associated with vascular toxicity [51], decreased BBB tight junctions and increased permeability [52], direct neurotoxic to neurons, and neuroin ammation [53]. The abnormal glycerophospholipid metabolism observed in this study may partially explain the occurrence of these injuries.…”
Section: Discussionsupporting
confidence: 52%
“…A growing number of studies have suggested that glycerophospholipid metabolites could serve as markers for the assessment of drug addiction [33,49,50], and our ndings demonstrated that this recommendation is equally applicable to MA addiction. Previous studies have shown that direct damage from MA exposure is associated with vascular toxicity [51], decreased BBB tight junctions and increased permeability [52], direct neurotoxic to neurons, and neuroin ammation [53]. The abnormal glycerophospholipid metabolism observed in this study may partially explain the occurrence of these injuries.…”
Section: Discussionsupporting
confidence: 52%
“…The established connection between stress and methamphetamine dependency [112,113] underscores the potential impact of MBIs in mitigating addictive behaviours by modulating stress reactivity and aiding stress recovery. Numerous studies employing heart rate variability (HRV) as an indicator of physiological reactivity and stress recovery reveal the positive effects of MBIs [114,115].…”
Section: Impact On Stress Reactivitymentioning
confidence: 99%